ORIGINAL_ARTICLE
Effect of Amindarone induced hyper thyriodism on bone remodeling process: histological and radiodensitometric analysis. (Experimental study in rats)
Objectives: The aim of the study was to evaluate the effect of Amindarone drug alone and in combination with cabbige on bone methabolism on both histological and radiographical .Subjects& Methods: 15 rats were allocated in three groups, in group (I) the rats received the amiodarone, group (II) rats received aminodarone and uncooked cabbage while group(III) serve as a control group, by the end of 13th week the rats were sacrified using an overdose of I.V. Phenobarbital.mandibles of the rats were subjected to histological and radiograghic examination .Results: on the radiographic examination of the rats’ mandible in group I that received the Amiodaron the bone density showed decrease with average of( 601 ± 203) while in group II that received the Amiodaron and cabbages showed less decrease in bone density with average of (730±160.4) than the control group (group III) that showed average of bone density of (830±139.5) there is a significant difference among the groups P<0.001.Conclusion: Amiodarone drug induced the hyperthyroidism in rats treated for 13 weeks. The use of un cooked cabbage decrease the changes in the bone in both histological and radiographic evaluations
https://edj.journals.ekb.eg/article_72184_bfaa1a1822db33bf9373e6e1f8f34b5d.pdf
2019-04-01
1149
1156
10.21608/edj.2019.72184
Amindarone
hyper thyriodism
Computed tomography
CT Bone density
Inass
Aboulmagd
1
Lecturer, Department of Oral Radiology, Faculty of Dentistry, Fayoum University
AUTHOR
Samah
Kamel
2
Lecturer, Department of Oral Biology, Faculty of Dentistry, October University of Modern Sciences and Art
AUTHOR
ORIGINAL_ARTICLE
Radiographic Evaluation of Bone Quality in Rheumatoid Arthritis Patients
Introduction: Rheumatoid arthritis is an inflammatory chronic, disease. Rheumatoid arthritis leads to swelling, stiffness, pain, and probable loss of function in numerous joints, including the TMJ. Patients on steroid medications usually suffer from: ease of infection osteoporosis and also they have a risk of the gingival inflammation at the implant sites if the patient is unable to maintain the oral hygiene measurements to control the plaque following the treatment. Due to these problems the Dentists hesitate to perform dental implant for them. Aim of the study: To evaluate the effect on the TMJ and the bone density in patients with RA and under treatment for a long time. Material and methods: 72 patients were divided into 3 groups: group A: 24 normal patients, group B: 24 patients with rheumatoid arthritis recently discovered, group C: 24 patients with rheumatoid arthritis for at least 10 years and are on a regular treatment and follow up. The angle of the mandible was measured to determine the effect on the TMJ, and some areas were selected to measure the bone density. Results: The results for the angle measurement showed a significant difference between the measured angle in the 3 groups. The biggest angles mean was group A (the control group), while the lowest mean was group C. Regarding the measured density in the 3 groups the highest density was measured in group A, while the least was measured in group C. Conclusion: There is a high correlation between the duration of the RA and the bone density and also an effect on the TMJ which affect the mandibular angle and convert the patient occlusion into skeletal class II despite receiving a treatment.
https://edj.journals.ekb.eg/article_72185_e13407ad6ef3b9eb800053ea2c09dec3.pdf
2019-04-01
1157
1162
10.21608/edj.2019.72185
Rheumatoid Arthritis
TMJ
bone density
dental implant
Mushira
Dahaba
1
Professor, Oral & Maxilofascial Radiology, Cairo University
AUTHOR
Ahmed
bakry
2
Assistant Professor, Oral & Maxilofascial Radiology, Minia University
AUTHOR
Walid
Salem
3
Lecturer, Oral & Maxilofascial Radiology, Beni Suef University
AUTHOR
ORIGINAL_ARTICLE
INFRABONY POCKETS IN CHRONIC AND AGGRESSIVE PERIODONTITIS. A CONE BEAM STUDY
The present research was conducted to explore the infra bony pockets in chronic and generalized aggressive periodontitis from the radiographic point of view using CBCT. A total of 150 infrabony pockets were included in the study obtained from 33 patients (20 females and 13 males). The defects were classified into 2 equal groups, 75 defects in chronic periodontitis (Group I), 75 in the generalized aggressive periodontitis (Group II). The Simplant program was used to measure the infrabony pocket depth, the vertical bone loss, the defect angulation, the bone density at the base of the defect, the defect volume. Also the percentage of furcation involvement and presence of calculus were recorded. Results showed higher rates of alveolar bone loss, wider defect angles, decreased bone density apical to the defects, larger defect volumes and more furcation involvement in Group II compared to Group I with statistically significant differences. On the other hand Group I showed significant percentage of calculus formation when compared to Group II. So it can be concluded that the multifactorial risk factors associated with generalized aggressive periodontics resulted in too much higher rates of periodontal destruction when compared to the chronic periodontitis group. Also the local factors play an important role in the pathogenesis of chronic periodontitis, but they are of little importance in generalized aggressive forms. The Simplant software technologies enabled measuring the defect volume which can aid in the estimation of the proper graft volume before surgery.
https://edj.journals.ekb.eg/article_72187_8996edd393c6684dd43df16fa7ddc76b.pdf
2019-04-01
1163
1172
10.21608/edj.2019.72187
Shereen
Abdel Moula
1
Associate Professor of Oral Medicine, Periodontology, Diagnosis and Radiology, Faculty of Dentistry, Tanta University.
AUTHOR
Hussein
Saudi
2
Professor of Oral Medicine, Periodontology, Diagnosis and Radiology, Faculty of Dentistry ,Tanta University
AUTHOR
ORIGINAL_ARTICLE
Effect of Combined Low Intensity Laser and Supplementary Micronutrients on the Healing Phase of Dental Implants
This study was aimed to assess the effect of low intensity laser (LIL) combined with supplementary micronutrients on the healing phase following endosteal dental implant insertion. Thirty implants were installed in the maxillary premolar regions of thirty male subjects of age ranged from 40-45 years old. Subjects were then randomly divided into three groups (I, II, and III), conventional, drug supplementation, and, laser groups. Following implant insertion, the healing phase of group (I) was left to progress spontaneously without any interference. Group (II) was given drug supplementation regimen for two months (one month before and one month after the implant surgery), while the implant insertion in laser group (III) was followed by low intensity (gallium arsenide diode) laser application with wavelength of 904 nm, an output power of 30 mWatts, and a frequency of 9999 Hz for 3 minutes in three sessions on three alternative days starting from the tenth post-operative day. A six month follow up period was applied radiographically to all subjects of both groups using sequential conventional radiographs. Radiographs were digitized by a professional scanner and bone density was recorded. The results revealed that drug therapy reduced the recommended healing time by 8% while laser therapy reduced the recommended healing time by 33%.
https://edj.journals.ekb.eg/article_72193_0555dac40c6ae265b68e7acfd10d88ef.pdf
2019-04-01
1173
1185
10.21608/edj.2019.72193
Tarek
Harhash
1
Assist. Professor of Laser Dental Applications, Department of Medical applications of Laser, National Institute for Laser Enhancement Sciences, Cairo University.
AUTHOR
ORIGINAL_ARTICLE
Influence of Low Intensity Laser Biomodulation on the Osseointegration of Delayed and Delayed-Immediate Implants
The aim of this study was to compare and contrast the influence of low-level laser therapy (LLLT) on the osseointegration of delayed and delayed-immediate dental implants. Forty implants were installed in the maxillary premolar regions of forty male subjects of age ranged 40-45 years old. Subjects were then randomly divided into four groups (I, II, III, and IV), delayed implant control group, delayed implant laser group, delayed-immediate implant control group, and delayed-immediate implant control group. Following implant insertion, the healing phase of groups (I and III) was left to progress spontaneously. Groups (II and IV) were subjected to low intensity (gallium arsenide diode) laser application with wavelength of 904 nm, an output power of 30 mWatts, and a frequency of 9999 Hz for 3 minutes in three sessions on three alternative days starting from the tenth post-operative day. A six month follow up period was applied radiographically to all subjects of both groups using sequential conventional radiographs. Radiographs were digitized by a professional scanner and bone density was recorded. The results revealed that low intensity laser therapy (LLLT) provided an easy as well as efficient method for accelerating bone healing and improving osseointegration whatever the technique used for implant insertion. The study concluded that laser could be used as additional aid for improving osseointgration and increasing the success rate for implantation protocols.Keywords: Laser, LLLT, Osseointegration, Dental Implant.
https://edj.journals.ekb.eg/article_72194_8eb0949ff7620d5e8fc3ba4bdf0932ad.pdf
2019-04-01
1187
1200
10.21608/edj.2019.72194
Laser
LLLT
osseointegration
dental implant
Tarek
Harhash
1
Asst. Professor of Laser Dental Applications, Department of Medical applications of Laser, National Institute for Laser Enhancement Sciences, Cairo University.
AUTHOR
ORIGINAL_ARTICLE
THE USE OF PLATELET-RICH FIBRIN COMBINED WITH FREE GINGIVAL GRAFT IN THE MANAGEMENT OF INSUFFICIENT ATTACHED GINGIVA AT TEETH WITH GINGIVAL RECESSION
Aim: This study was carried to evaluate the effect of the placement of PRF membrane beneath the free gingival graft in gingival augmentation surgeries regarding the changes by time in graft horizontal dimension, vertical dimension and total surface area.Subjects and Methods: Sixteen patients were selected. All the patients showed gingival recession with insufficient attached gingiva. The gingival augmentation surgery was decided to be performed as a primary surgery to increase the attached gingiva with no attempt to cover the recession during this study. Group 1 (test group) included eight patients where the gingival augmentation was performed using a free gingival graft in combination with a platelet rich fibrin membrane placed beneath the graft at the recipient site. Group 2 (control group) included eight patients where the gingival augmentation was performed using a free gingival graft only. The graft vertical dimension (GVD) and the graft horizontal dimension (GHD) were measured using William’s graduated periodontal probe. Plaque index, gingival bleeding index and probing depth were used to monitor the oral hygiene status and gingival health condition throughout the study. All the measures were obtained at 2 occasions; the day of the surgery and 1.5 months after the surgery.Results: Regarding the changes in GVD, a statistically significant greater mean and median percent decrease was noted in group 2 after 1.5 month. The same was obtained with the changes in GHD and graft surface area.Conclusion: Using platelet-rich fibrin beneath free gingival graft in gingival augmentation surgery resulted in successful increase in the attached gingiva with less dimensional changes by time in the transplanted free gingival graft compared to using free gingival graft alone.
https://edj.journals.ekb.eg/article_72196_51f4fe597a3a86f21267765f3c136952.pdf
2019-04-01
1201
1215
10.21608/edj.2019.72196
Ahmed
Amr
1
Lecturer of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University
AUTHOR
ORIGINAL_ARTICLE
Decreased VEGF and Cyclin D1 Genes Expression Enhances Chemosensitivity of Human Squamous Cell Carcinoma Cells to 5-Fluorouracil and/or Mesenchymal Stem Cells-Derived Microvesicles
Background: Among the most common oral cancers is oral squamous cell carcinoma which has high rates of mortality. 5-flurouracil (5-FU) is a widely used chemotherapeutic agent for treatment of head and neck cancers. However, its use has many limitations due to its well- known side effects. Thus, in the current study we aimed to investigate the chemosensitivity of squamous cell carcinoma cells to 5-FU and/or mesenchymal stem cells-derived microvesicles via H&E histopathological examination, in addition to detection of vascular endothelial growth factor (VEGF) and cyclin D1 (CD1) genes’ expression through quantitative RT-PCR analysis. Material & Methods: Human squamous cell carcinoma cell line (SCC152) was treated by 5-FU or Microvesicles or their combination for 24 and 48 hours. Histopathological examination through H&E stain as well as quantitative RT-PCR analysis, for gene expression of VEGF and CD1, were performed. Finally, statistical analysis of the obtained data and correlation between VEGF and CD1 genes’ expression among different groups were performed. Results: Regarding the histopathological results, the combination group, as compared to 5-FU or microvesicles treated groups, showed the most obvious improvement where numerous apoptotic bodies were observed at 24hrs, being markedly increased at 48hrs of culture, while viable cells were rarely seen. Concerning the qRT-PCR results, the combination group showed significant decrease in genes’ expression of both VEGF and CD1 than the 5-FU or microvesicles treated groups. Furthermore, correlation between VEGF and CD1 genes’ expression revealed a very good positive correlation.Conclusions: it was concluded that the combined use of microvesicles and 5-FU resulted in enhanced chemosensitivity of squamous cell carcinoma cells more than the use of either 5-FU or microvesicle alone. In addition, down regulation of VEGF gene expression was associated with decreased CD1 gene expression.
https://edj.journals.ekb.eg/article_72197_1705922105b3b2cd6afb40c362cb26c6.pdf
2019-04-01
1217
1228
10.21608/edj.2019.72197
squamous cell carcinoma cell line
5-flourouracil
Microvesicles
vascular endothelial growth factor
cyclin D1
Ghada
Abd El Latif
1
Lecturer of Oral Pathology, Department of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismalia, Egypt
AUTHOR
Iman
Aboushady
2
Assitant professor of oral biology, Department of Oral Biology, Faculty of Dentistry, Cairo University
AUTHOR
Dina
Sabry
3
Professor of Medical Biochemistry and Molecular Biology, Department of Medical Biochemistry and molecular biology, Faculty of medicine, Cairo University
AUTHOR
ORIGINAL_ARTICLE
Impact of hormonal replacement therapy on the tongue mucosa of ovariectomized albino rats receiving Triptorelin
Introduction: Menopause is defined as the cessation of menstruation, which is usually common in life’s fifth decade in most women. The post-menopausal women usually complain of multifarious oral manifestation that develop overtime. Impact of hormonal replacement therapy not only alleviate the side effects but also enhance the oral wellbeing. However, this needs further research to be more justifiable.Aim of study: 1) to investigate degenerative changes in the tongue epithelium of ovariectomized albino rats and 2) to study the effects of hormonal replacement therapy in attenuation of epithelial cell degeneration.Materials & methods: Thirty adult albino female rats were divided into three equal groups: Group I: Control group, Group II: Rats were injected for 75 days with daily dose of 160μg of triptorelin intraperitoneally, Group III: Rats were injected for 75 days with daily dose of 160μg of triptorelin intraperitoneally followed by hormonal replacement therapy of estrogen for 14 days. By the end of the experimental periods all animals were sacrificed and the tongue of all rats were dissected and processed for light and immunohistochemical examinations. Results: Examination of dorsal surface of rat’s tongues in control group revealed normal epithelium with normal taste buds & connective tissue but the epithelium, taste buds cells and connective tissue in-group II were found to be destructed, group III revealed regeneration of focal areas of destruction that was seen in-group II. Immunohistochemical examination of PCNA expression of control group showed moderate PCNA expression, while group II showed weak PCNA expression, group III showed high PCNA expression.Conclusion: Hormonal replacement therapy can relieve the oral signs and symptoms and improve the oral well-being in menopausal women.
https://edj.journals.ekb.eg/article_72199_77d2086b6d940eed40bfff9e93cdacc3.pdf
2019-04-01
1229
1235
10.21608/edj.2019.72199
Menopause
Triptorelin
PCNA
Estrogen
Sally
Abo Baker
1
Lecturer of Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt
AUTHOR
ORIGINAL_ARTICLE
Chemopreventive effect of capsaicin in experimentally induced hamster buccal pouch carcinogenesis (Immunohistochemical study Bcl-2)
Aim:To investigate immunohistochemically the effect of chemopreventive capsaicin in epithelial alteration (Epithelial dysplasia) & carcinogenesis which induced in hamsters. Methods: Hematoxylin and Eosin (H&E) and Streptavidin-biotin immunoperoxidase staining techniques was used to detect the expression of Bcl-2 in three groups (G1, G2 and G3). Evaluation of immunostaining was done using computer image analyzer system & statistical analysis. Results: showed that there was a statistically highly significant difference (P<0.01) in means values of all groups (G2>G1, G3) (G3>G1). Conclusion:Capsaicin play an important role in reduction and prevention of transformation of epithelial dysplasia into malignant tumor especially oral squamous cell carcinoma. The liquid form of capsaicin may be considered as a new line of treatment in oral dysplasia or even in oral squamous cell carcinoma and the Bcl-2 expression evidenced this reduction of abnormality in epithelial dysplasia.
https://edj.journals.ekb.eg/article_72201_118e05df5971015f6d065ac34d839a02.pdf
2019-04-01
1237
1243
10.21608/edj.2019.72201
Oral Epithelial Dysplasia
chemopreventive effect
Capsaicin
Bcl-2
induced hamster carcinogenesis
Mohamed
Mohamed
m.abdelrahman@tudent.edu.sa
1
Assistant Professor of Oral Pathology , Faculty of Dentistry , Al-Azhar University
AUTHOR
Ali
AlQarni
2
Teaching Assistant of Oral Medicine , Faculty of Dentistry , Taif University
AUTHOR
ORIGINAL_ARTICLE
ADMINISTRATION OF SYSTEMIC PROPOLIS VERSUS MOXIFLOXACIN AS ADJUNCTIVE TREATMENT OF SEVERE GENERALIZED PERIODONTITIS
To-date, emerging bacterial resistance to the commonly prescribed antibiotics in the management of periodontitis has become a challenging problem making scientists continually seek for new agents. In the present study, propolis (PRO) (natural bee glue) and moxifloxacin (MXF) (new quinolone antibiotic) were evaluated in the treatment of severe generalized periodontitis (gP) as adjuncts to scaling and root planing (SRP). Fifty four subjects with severe gP were randomly assigned into three groups (3 subjects did not complete the study after participation). Group I in which SRP alone was performed to gP patients (SRP group; n=17); group II in which SRP was done to gP patients combined with orally administered propolis 400 mg once daily for 7 days (PRO group; n=16); and group III in which SRP was performed to gP patients combined with oral moxifloxacin 400 mg once daily for 7 days (MXF group; n=18). Pocket depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), plaque (PI) and gingival (GI) indices were recorded at baseline, after 6 and 12 weeks of SRP. Salivary interleukin-1 beta (IL-1β) was evaluated at the same time points for all groups. All three procedures led to significant reductions in PD, CAL, BOP, PI and GI after 6 and 12 weeks. PD reduction and CAL gain were significantly greater in the PRO and MXF groups compared to SRP group at 6 and 12 weeks after therapy (p < 0.01). Importantly, there was no significant variation between PRO group and MXF group after treatment (p > 0.05). Likewise, in PRO and MXF groups, the salivary inflammatory marker (IL-1β) was significantly reduced in comparison to SRP group (p < 0.01). In all groups, salivary IL-1β levels were decreased at 6 and 12 weeks compared to baseline values. It was concluded that the adjunctive use of PRO and MXF to SRP had significantly improved the treatment outcomes in subjects with severe gP comparable to SRP alone. Thus, PRO and MXF showed promising results in the treatment of periodontal disease. KEYWORDS Propolis, Moxifloxacin, Adjunctive treatment, Periodontitis.
https://edj.journals.ekb.eg/article_72202_25dc5ed949713f5eb42a4ac59c75a353.pdf
2019-04-01
1245
1255
10.21608/edj.2019.72202
Propolis
Moxifloxacin
Adjunctive treatment
Periodontitis
Mohamed
Anees
1
Assistant Professor of Oral Medicine & Periodontology, Faculty of Dentistry, Mansoura University.
AUTHOR
Tamer
Aboshady
2
Lecturer of Oral Medicine & Periodontology, Faculty of Dentistry, Tanta University
AUTHOR
Hesham
El-Sharkawy
3
Professor of Oral Medicine & Periodontology, Faculty of Dentistry, Mansoura University.
AUTHOR
ORIGINAL_ARTICLE
A trial of thymoquinon loaded on gold nanoparticle as a therapy for induced squamous cell carcinoma in buccal pouch of hamster
Objectives: Combining the anti - tumor effect of thymoquinone (TQ) with the efficient penetration of gold nanoparticles (GNPs) into cells and nuclei as an attempt to treat the induced oral squamous cell carcinoma in buccal pouch of hamster. Materials and methods: This study was carried out on forty two male Syrian golden hamsters (n=42), its age ranged from 6 to 7 weeks, weighting 90-110 gm. Animals were housed with controlled temperature and were given pellets formed of seeds, grain, cracked corn and tap water ad libitum. The hamsters were divided into: Group A: (Control groups) n=24, Group A1: eighteen animals (n=18) were served as “negative control” . Sub-group A1a: Six animals were sacrificed at day zero. Sub-group A1b: Six animals were sacrificed at 14th week. Sub-group A1c: Six animals were sacrificed at 20th week. Group A2: Six animals (n=6) were considered as “positive control”. DMBA was painted to the left cheek pouches, three times /week for 14weeks. Group B: Eighteen animals (n=18) were painted with DMBA to left cheek pouches three times/week for 14weeks, and subdivided into: Sub-group B1: Six animals were injected intra-peritoneal with GNPs/3 times/week for six weeks. Sub-group B2: Six animals were injected intra-peritoneal with TQ/3 times/week for six weeks.Sub-group B3: Six animals were injected intra-peritoneal with GNPs-TQ/3 times/ week for six weeks. All pouches were extracted and prepared to examined through histological examination for any structural changes and immunohistological detection of COX2. Results: Improve superior anti-inflammatory role of TQ when loaded with GNPS in COX-2 retardation and tumor size regression. Conclusion: Thymoquinon loaded on nanogold particle showed protective role in the oral cancer.
https://edj.journals.ekb.eg/article_72204_5a103067d2d2071701b10cbdc5055197.pdf
2019-04-01
1257
1266
10.21608/edj.2019.72204
Thymoquinon
Nano gold particles
oral cancer
COX
Mona
Shata
1
Lecturer of Oral Pathology Department, Faculty of Dentistry, Suez Canal University
AUTHOR
Rasha
Taha
2
Lecturer of Oral Biology Department, Faculty of Dentistry, Suez Canal University
AUTHOR
ORIGINAL_ARTICLE
Assessment of anterior maxillary alveolar bone dimensions and morphology for immediate implant planning: A retrospective study using Planmeca Promax CBCT unit
Objectives: To evaluate the dimensions and morphology of the alveolar bone in the maxillary central, lateral and canine regions and to correlate these findings with the age and gender of each subject to provide detailed information for immediate implant planning.Subjects & methods: 112 CBCT scans of both genders with non-extracted maxillary right central, lateral and canine were obtained from the database of the Oral and Maxillofacial Radiology Department, Faculty of Dentistry, Cairo University. For each of the three right maxillary anterior teeth bone height was measured from the crest of the ridge till the nasal floor. The bone width was measured at three levels, namely the cervical, the middle and the apical level. The presence and depth of buccal undercuts was also assessed at the three locations. Additionally, the cross-sectional morphology of the alveolar ridge was determined and classified into three different types.Results: The results of this study showed that the bone height at the right central incisor had the least values; meanwhile the canine had the greatest values. Regarding the bone width, the region of the lateral incisor had the thinnest alveolar ridge at the three levels. In all the three locations however, the alveolar width was greater apically than cervically. Besides, the lateral incisor region showed the highest prevalence for presence of buccal undercuts. The greatest depth of buccal undercut however was found in the canine region, meanwhile the smallest depth was found in the central incisor region. For the cross-sectional morphology, Type I (bell-shape) was the most common in all three locations while Type III (hourglass-shape) was the least common. Age did not affect any of the examined parameters. Males showed more height and width of the alveolar bone, while females showed higher prevalence and greater depth of buccal undercuts in all three locations. Males also showed a greater prevalence of Type I (bell-shape) cross-sectional alveolar bone shape, meanwhile females showed a greater prevalence of Type II (trapezoid-shape) and Type III (hourglass-shape).
https://edj.journals.ekb.eg/article_72207_73ca2664112d266ceecebffc46914083.pdf
2019-04-01
1267
1278
10.21608/edj.2019.72207
Anterior maxilla
CBCT
Implant
alveolar bone dimensions
buccal undercut
Dina
Ahmed
1
Lecturer of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University.
AUTHOR
Dina
El Beshlawy
2
Associate Professor of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University.
AUTHOR
ORIGINAL_ARTICLE
Comparative Evaluation of Coronally Advanced Flap Using Platelet-rich Fibrin Membrane and Fresh Amniotic Membrane in Gingival Recession
Background: the aim of this study was to evaluate and compare the effectiveness of root coverage with coronally advanced flap combined with Platelet Rich Fibrin or Fresh Amniotic Membrane. Materials and Methods: thirty patients had Miller class I or II in maxillary anterior teeth were involved in the present study. Each recession defect was randomly assigned to one of the treating groups: coronally advanced flap with Platelet rich fibrin (PRF group) and coronally advanced flap with fresh amniotic membrane (AM) (AM Group). Clinical measurements of recession depth (RD), root coverage percentage (RC%) pocket depth (PD), clinical attachment level (CAL) and width of keratinized tissue (WKT) were evaluated at the baseline, three months, six months and nine months postoperatively. Statistical analysis was performed for intergroup and intragroup comparisons respectively. Results: intragroup comparison displayed statistical significant difference with regard to RD and CAL at different time interval. No statistical significant difference between groups at different time interval with regard to RD, PD, CAL while WKT, AM group demonstrated statistical significant increase compared to PRF group. Conclusion: Both the membranes provided successful and predictable root coverage when combined with CAF. AM was more effective in terms of increase in WKT.
https://edj.journals.ekb.eg/article_72211_fb5321ee4dea3a3e75d647340527873e.pdf
2019-04-01
1279
1290
10.21608/edj.2019.72211
Gingival recession
coronally advanced flap
Platelet rich fibrin
Fresh amniotic membrane
Hany
Shalaby
1
Assistant Professor of Oral Medicine and Periodontology Faculty of Dentistry Suez Canal University
AUTHOR
Shaimaa
Morsy
2
Lecturer of Oral Medicine and Periodontology Faculty of Dentistry Suez Canal University.
AUTHOR
ORIGINAL_ARTICLE
Parenchymal Down Regulation and Enhanced Stromal Expression of Syndecan-1 in Oral Squamous Cell Carcinoma
Background and aim: In normal stratified squamous epithelia, syndecan-1 works as cell adhesion molecule, and exhibits an important role in the regulation of cell growth and differentiation during the development. It is recognized as tumor marker with diagnostic and prognostic role in different cancer types. This study was planned to explore the role of syndecan-1 in oral squamous cell carcinoma.Materials and Methods: Twenty two cases were histologically diagnosed as Oral Squamous Cell Carcinoma (OSCC) that simultaneously contained dysplastic epithelium and carcinoma in situ (CIS) foci. Immunohistochemical staining for syndecan‑1, alpha smooth muscle actin and Ki-67 were done.Results: Decreased expression of syndecan-1 from normal epithelia to CIS. In OSCC parenchyma, transition from cell membrane localization into cytoplasm was detected. In addition, strong expression of syndecan-1 in stromal fibroblasts was observed.Conclusion: Decreased expression of syndecan-1 in parenchymal cells together with its appearance in stromal fibroblasts might be used as a reliable tool in oral squamous cell carcinoma early diagnosis.
https://edj.journals.ekb.eg/article_72553_3a64516a67923fa785dba6af32b0fac0.pdf
2019-04-01
1291
1296
10.21608/edj.2019.72553
Syndecan-1
parenchymal
stromal
Oral squamous cell carcinoma
Ahmed
Essa
1
Lecturer of Oral Pathology, Oral Pathology Department, Tanta University, Egypt, Assistant Professor of Oral Pathology, Faculty of Dentistry, Al-Baha University, Kingdom of Saudi Arabia
AUTHOR
Mahmoud
Attia
2
Assistant Professor of Oral Pathology, Oral Pathology Department, Faculty of Dental Medicine Al-Azhar University, Egypt, Associate Professor of Oral Pathology, Faculty of Applied Medical Science, Al-Baha University, Kingdom of Saudi Arabia
AUTHOR
ORIGINAL_ARTICLE
Speculation of the Cytotoxic Effect of Cisplatin Either Necrosis or Apoptosis and the Possible Antagonist Protective Role of Acetyl L-Carnitine, In vitro Study
Background: Cisplatin is one of mostly used chemotherapeutic drugs. Eventhough, cisplatin drawbacks limit its use. Acetyl L- Carnitine is a neuro-protective and anti-oxidant agents as well as it has anti-apoptotic properties.Aim of the study: this study was designed to evaluate the mechanism of Cisplatin to influence tissue in the pathway of apoptosis or the pathway of necrosis and the protective role of Acetyl-L-Carnitine against cytotoxicity induced by Cisplatin in the dental pulp. Material and methods: Total of 30 male albino rats (250-300 grams) were divided equally into three groups where saline was given to the control group (Group I), Cisplatin was injected into group II the (Cisplatin Group), and L- Carnitine was given to the Group III (L- Carnitine group + Cisplatin) before the injection of Cisplatin. After sacrificing the rats one week later, the extraction and preparation of their jaws were carried out in order to examine their dental pulp histologically histologically and immunohistochemically. Results: The light microscopic results showed degeneration in the dental pulp tissue of group II animals represented by cytoplasmic vacuolization, idiopathic calcification, hyaline and fatty degeneration. While group III showed normal dental pulp tissues with dilated blood vessels. Immunohistochemical examination showed significant differences in group II when compared to control group for both Bax (p=0.0002) and TNF-α (p=0.0029). No significant differences appeared in group III when compared to control group for both Bax and TNF-α. Significant differences were evident in comparison between group II and group III for both Bax (p=0.0015) and TNF-α (p=0.000001).Conclusion: Cisplatin has a devastating effect on dental pulp tissues via both the apoptosis and necrosis pathways. L-Carnitine had a protective effect against the cytotoxicity of Cisplatin.
https://edj.journals.ekb.eg/article_72554_0ad7160d88e90f49bc4dcd80825bc08b.pdf
2019-04-01
1297
1309
10.21608/edj.2019.72554
Cisplatin
L-carnitine
BAX protein
Tumour Necrosing Factor
Rasha
Taha
1
Lecturer in Oral Biology Department, Faculty of Dentistry, Suez Canal University
AUTHOR
Rania
Said
2
Assistant professor in Oral Pathology Department, Faculty of Dentistry, Suez Canal University
AUTHOR
ORIGINAL_ARTICLE
The Effectiveness of Vitamin D Supplementation in Chronic Periodontitis Patients: a Randomized Controlled Clinical Trial
Background : Vitamin D deficiency is a common health problem worldwide and linked to some infectious and inflammatory conditions, including periodontal disease. This is a double blind randomized controlled study to evaluate the clinical effectiveness of Vitamin D supplementation as an adjunct therapy to non-surgical periodontal treatment in healthy middle-aged vitamin D deficient patients with chronic periodontitis. Material and Methods: Twenty eight patients with mild to moderate chronic periodontitis were included in this study . They were randomized to two groups: Test Group taking oral Vitamin D supplementation 10,000 IU one tablet daily for five days per week for a total duration of 12 weeks and Control Group taking placebo pills. Both groups were maintained on scaling and root planning sessions. Data was collected at baseline and at three months including the following clinical periodontal parameters: Gingival index (GI), Plaque index (PI), Probing pocket depth (PPD) and Clinical attachment level (CAL). Results: Intra-group analysis showed that both groups had significant improvements in the periodontal measures. However, analysis comparing changes in the mean periodontal indices between groups showed that the mean changes across all periodontal indices between groups were statistically significant at pConclusion: Adjunctive low cost Vitamin D supplementation in mild to moderate chronic periodontitis in middle aged Vitamin D deficient healthy patients significantly improves clinical periodontal outcomes relative to scaling and root planning alone with no side effects. Vitamin D is safe and probably may contribute to decrease health care costs as an adjunctive therapy to conventional periodontal treatment.
https://edj.journals.ekb.eg/article_72555_fe54fa2d54268744d462130396721609.pdf
2019-04-01
1311
1321
10.21608/edj.2019.72555
Chronic Periodontitis
vitamin D deficiency
periodontal diseases/drug therapy
calcitriol/therapeutic use
Assaf
M
1
Oral Surgical Sciences Department, Division of Periodontology, Faculty of Dentistry, Beirut Arab University, Lebanon
AUTHOR
Nayer
Aboelsaad
2
Associate Professor, Periodontology, Faculty of Dentistry, Beirut Arab University, Lebanon; and Faculty of Dentistry, Mansoura University, Egypt.
AUTHOR
ORIGINAL_ARTICLE
Clinical efficacy of diode laser alone and in combination with desensitizing varnish in dentinal hypersensitivity treatment (Randomized Controlled Trial)
This study aimed to evaluate the efficacy of diode laser alone and with topical sodium fluoride varnish on reducing dentine hypersensitivity (DH) in patients with chronic periodontitis. Materials and Methods: Forty patients having stage I and Stage II periodontitis were selected according to the criteria of AAP (2017) with complaint of (DH) after routine periodontal therapy . Patients were randomly divided into two groups: group1- received NaF varnish then diode laser application at 1 W (PW) ,(CW) for 30 seconds using 320µ fiber. Group-2, treated with laser irradiation only. Each tooth received three application Dentine hypersensitivity evaluation was by tactile, air-blast, and thermal stimuli and measured using VAS scores. The patient’s response was recorded at baseline, one month and 3 month after the applicationResults : The results were statistically analyzed, significant pain reduction was showed in both groups. However , it was found that in the laser plus varnish group, tangible reduction in dentine hypersensitivity scores more than in laser alone group on the three tested stimuli at one and three months. VAS score differences between the groups were statistically significant Conclusion : It was concluded that diode laser plus NaF varnish is more effective than laser alone in reduction of patients’ dentine hypersensitivity among chronic periodontitis patients.
https://edj.journals.ekb.eg/article_72556_1682dc3d59eecefe852ba81ec89c10fd.pdf
2019-04-01
1323
1328
10.21608/edj.2019.72556
Diode laser
Chronic Periodontitis
Desensitizing agent
dentine hypersensitivity
Nayer
aboelsaad
1
Associate Professor of Periodontology, Faculty of Dentistry, Beirut Arab University, Lebanon, Faculty of Dentistry, Mansoura University, Egypt.
AUTHOR
Mohmed
Attaf
2
Professor of Restorative Dentistry, Faculty of Dentistry, Beirut Arab University, Lebanon
AUTHOR
ORIGINAL_ARTICLE
Curcumin Topical Application For Symptomatic Treatment of Oral Lichen Planus: A Systematic Review of Evidence
Objective: The aim of this systematic review was to assess the clinical effectiveness of topical curcumin, compared to topical corticosteroids for the management of symptomatic oral lichen planus.Material & Methods: Three databases were searched including MEDLINE-PubMed, Cochrane-Central & LILACS as well as Grey literature & hand-searching till September 2018. Randomized and non-randomized controlled clinical trials relevant to our topic were comprised.Results: Four studies met our eligibility criteria and were included in this systematic review; 2 randomized and 2 non-randomized controlled trials. All included studies reported clinical improvement of oral lichen planus, in terms of pain alleviation as well as reduction in erythema and ulceration, with the topical use of curcumin. No statistical significant differences were found when comparing the effectiveness of topical curcumin to topical corticosteroids. Conclusion: Topical curcumin application shows promising effects, comparable to topical corticosteroids for the symptomatic treatment of OLP, with no adverse effects.
https://edj.journals.ekb.eg/article_72557_d4db14c6b2fedc1d8b49787c6da3cd7f.pdf
2019-04-01
1329
1339
10.21608/edj.2019.72557
Curcumin
Turmeric
Oral lichen planus
systematic review
Gihane
Madkour
1
Associate Professor of Oral Medicine, Diagnosis & Periodontology, Faculty of Dentistry, Cairo University, Egypt
AUTHOR
Amal
Hussine
2
Lecturer of Oral Medicine, Diagnosis & Periodontology, Faculty of Dentistry, Cairo University, Egypt
AUTHOR
Sandy
Hassan
3
Lecturer of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Fayoum University, Egypt
AUTHOR
ORIGINAL_ARTICLE
A STUDY TO DETECT THE SAFETY OF ELECTRONIC CIGARETTE ON THE TASTE BUDS OF ALBINO RATS TONGUE PAPILLAE
Background: Electronic cigarette is a substitute to traditional nicotine smoke invented since 2004. There is no enough data about its safety with its the widespread usage.Aim of the study: The present study was designed to verify the impact of E-liquid of electronic cigarette on taste buds of fungiform papillae in albino rats.Materials and methods: 22 young adult male albino rats were divided into 3 groups. Group I: (control group), injected i.p by normal saline daily. Group II: (E-cigarette group): animals were injected i.p by E-cigarette refill liquid (ECRL) containing 0.5 mg of nicotine/kg for 6 days then continue to be administered the same dose day after day for 4 weeks. Group III (E-cigarette + vitamin C treated group): animals had been i.p injected by (ECRL) containing 0.5 mg of nicotine/kg. One hour from i.p injection of the liquid, the animals were received vitamin C 300 mg/ kg through oro-gastric gavage for 6 days. Then animals were receive the regimen day after day till the end of 4 weeks. Rats of groups sacrificed 24 hs from last injection. After processing the tissue samples, they were stained using Haematoxylin & Eosin and Cytokeratin 7 & TNF α. The results were analyzed statistically using one way ANOVA test.Results: Evaluation of the sections revealed significant differences between all groups with marked improvement in group III. p value was less than 0.05.Conclusion: E-cigarette smoking has a harmful effect on taste buds of fungiform papilla histologically and immunohistochemically. Vitamin C has a protective effect on taste bud against E-cigarette refill liquid.
https://edj.journals.ekb.eg/article_72558_6bd380a342bc33cf639cbee6516fdf5d.pdf
2019-04-01
1341
1348
10.21608/edj.2019.72558
Mohamed
Abdelrahman
1
Associate Professor of Oral Biology, Faculty of Dentistry, Mansoura University
AUTHOR
Mahmoud
Elsherbeny
2
Lecturer of Oral Pathology, Faculty of Dentistry, Mansoura University
AUTHOR
ORIGINAL_ARTICLE
Comparison of Root Resorption Pattern in Human Primary Teeth under Physiologic and Coexistent Pathological Conditions
Background: Primary teeth are excellent model to figure out the differences in morphological and histological features of tooth resorption. They may be exfoliated due to physiological resorption of their roots or the coexistent physiological and pathological resorption that are usually observed in the replacement period of dentition. Aim: The aim of this study was to evaluate the qualitative differences in the appearance of the roots of primary teeth undergoing physiological or coexistent physiological and pathological root resorption. Material and Methods: Twenty primary teeth were examined, Ten exfoliated teeth with physiological resorption represented Group I and ten extracted teeth with coexistent physiological and pathological resorption represented Group II. Results: At light microscopic examination, group I showed deep round wave like resorption fossae filled with many odontoclasts, and the pulp showed inflammatory cell infiltration along with areas of dystrophic calcification. The odontoblasts were disorganized or disappear completely. Repair by cementum like tissue deposition was found internally. SEM examination revealed variable sized numerous resorption lacunae with smooth edges that had a circular or polygonal shape. Group II showed irregular resorbed root surface and various size odontoclasts besides thick granulation tissue. The pulp was degenerated, necrotic and contained calcification globules. The odontoblastic layer couldn’t be identified. Cementum repair was evident externally but at the internal resorption surface. By SEM, the resorption fossae were smaller and irregular in shape with thinner edges.Conclusion: There were various morphological differences between physiological and coexistent physiological and pathological resorption of human primary teeth
https://edj.journals.ekb.eg/article_72559_190d85efa85efe43aeca6d865a9a6c95.pdf
2019-04-01
1349
1358
10.21608/edj.2019.72559
Human Primary teeth
Pathological Root resorption
Physiological Root resorption
Scanning electron microscope
Gihan
Hassan
1
Lecturer of Oral Biology, Faculty of Dentistry, Tanta University, Egypt. Faculty of Dentistry, El-Giesh St., Tanta, Gharbia, Egypt.
AUTHOR
Dalia
Zahran
2
Ass. Prof. of Oral Biology, Faculty of Dentistry, Tanta University, Egypt. Faculty of Dentistry, El-Giesh St., Tanta, Gharbia, Egypt.
AUTHOR
Reda
Saleh
3
Lecturer of Oral Biology, Faculty of Dentistry, Tanta University, Egypt. Faculty of Dentistry, El-Giesh St., Tanta, Gharbia, Egypt.
AUTHOR
ORIGINAL_ARTICLE
HISTOLOGICAL EVALUATION OF THE ROLE OF ZINC OXIDE NANOPARTICLES ON SUBMANDIBULAR SALIVARY GLANDS IN RATS AND THE PROPHYLACTIC EFFECT OF QUERCETIN
Introduction: Nanoparticles have different effects on humans as they have specialized characteristics from the bulk materials. Zinc oxide nanoparticles are most commonly utilized nowadays due to their unique characteristics. On the other hand Zinc oxide nanoparticles have been found to have adverse effects on humans as cytotoxicity so it is a double-edged sword. Quercetin is a flavonol with beneficial anti-oxidant and antiinflammatory effect. Aim :The present work aimed to investigate the effects of Zinc oxide nanoparticles on rat submandibular glands and to evaluate the prophylactic effect of Quercetin . Materials and Methods: Twenty four male rats were equally divided into three groups: group A control, group B treated with Zinc oxide nanoparticles and group C treated with Zinc oxide nanoparticles and Quercetin for twenty eight days. Results: At the end of the study, rats were sacrificed and the effects of Zinc oxide nanoparticles as well as the prophylactic role of Quercetin on the submandibular glands were evaluated by light microscopy. The cells of the acini in group B revealed signs of cytotoxicity as loss of the acinar architecture, apoptotic nuclei, and cytoplasmic vacuolation while, in group C submandibular glands showed accentuated preservation in the cells of the acini and ducts that was comparable to that of the controls. Conclusion: This experiment clarified that Zinc oxide nanoparticles has a cytotoxic effect and illustrated that prophylactic administration of Quercetin efficiently counteracted the toxic effect of Zinc oxide nanoparticles administration in rat models. Therefore, Quercetin can be prophylactically used to prevent Zinc oxide nanoparticles cytotoxicity.
https://edj.journals.ekb.eg/article_72560_0c8b7ea59155a0b27521962d171c77da.pdf
2019-04-01
1359
1366
10.21608/edj.2019.72560
Zinc Oxide Nanoparticles
Quercetin
histology
Sara
Hamza
1
Lecturer of Oral Biology – Faculty of Dentistry – Alexandria University
AUTHOR
ORIGINAL_ARTICLE
Immunoexpression of Ki-67 and Cyclooxygenase-2 in Odontogenic Keratocyst and Dentigerous Cyst: A Comparative Study
Aims: To evaluate the expression of Cyclooxygenase-2 (COX-2) in odontogenic keratocyst (OKC) and dentigerous cyst and correlate it with Ki-67 expression in these lesions.Material and Methods: This study was carried out on 32 paraffin embedded specimens of dentigerous cyst and OKC. 16 samples obtained from healthy mucosa served as controls. Slides prepared from paraffin-embedded sections were immunohistochemically stained for Ki-67 and COX-2 and immunoreactivity of the two markers was evaluated using index of positivity and staining intensity. Statistical analysis was performed using Mann-Whitney and Spearman’s correlation tests.Results: Ki-67 and COX-2 expression in OKC and dentigerous cyst was found to be significantly higher than those observed in healthy mucosa groups (p < 0.05). The expression of the two markers was significantly higher in OKC than in dentigerous cyst. A positive correlation was found between the two markers in both lesions.Conclusions: Increased expression of Ki-67 and COX- 2 in OKC is an indicator of the high mitotic activity of these lesions compared with dentigerous cyst. COX-2 is implicated in odontogenic epithelial proliferation in OKC and dentigerous cyst.
https://edj.journals.ekb.eg/article_72561_b60a216adb184f75df93e426900efe88.pdf
2019-04-01
1367
1375
10.21608/edj.2019.72561
Ki-67
COX-2
OKC
dentigerous cyst
Enas
Abd El-Aziz
1
Lecturer of Oral and Maxillofacial Pathology, Faculty of Dentistry, Minia University.
AUTHOR
ORIGINAL_ARTICLE
Clinical and Cone-beam Computed Tomography Evaluation of Xenograft alone or in combination with Platelet Rich Fibrin in the Treatment of Grade II Mandibular Furcation Involvement
Aim of study: The aim of this study was to compare the effect of Xenograft alone or in combination with Platelet rich fibrin (PRF) in the treatment of mandibular furcation grade II defects.Patients and methods: Twenty patients with a total number of 40 grade II furcation defects in split mouth design determined clinically and radiographically were selected for the study. The selected sites were treated with open flap surgery and divided into two groups: Group I was treated with Xenograft (cerabone®) only and Group II treated with Xenograft (cerabone®) plus PRF membrane. The clinical and radiographic evaluation occurred at baseline (before surgery) and 6 month post-operative. Clinical parameters include: plaque index (PI), gingival index (GI), vertical clinical attachment level (VCAL) and Horizontal clinical attachment level (HCAL). Cone-beam Computed Tomography (CBCT) was performed to measure furcation height (FH), width (FW), and depth (FD) defects of mandibular molars at baseline (before surgery) and 6 month post-operative.Results: Both groups showed statistically significant reduction in all clinical and radiographic parameters within groups from baseline to 6 months post-operative. HCAL, FH, FW and FD were significantly increased in G II compared to G I at 6 months post-operative.Conclusion: Treatment of furcation grade II defects with xenograft (cerabone®) plus PRF led to significant improvement more than xenograft (cerabone®) alone.
https://edj.journals.ekb.eg/article_72562_2feafdd43db6187e1a0cead0c8ec68c2.pdf
2019-04-01
1377
1387
10.21608/edj.2019.72562
CBCT
platelet‑rich fibrin (PRF)
Xenograft
furcation grade II defect
Ahmed
Khalil
1
Lecturer of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Minia University. Egypt
AUTHOR
ORIGINAL_ARTICLE
Assessment of salivary and gingival crevicular fluid Periostin levels in chronic periodontitis patients before and after non-surgical periodontal therapy
Introduction: Periostin is a matricellular protein highly expressed by the fibroblasts in the periodontal ligament. It is entangled in the maintenance of periodontal integrity which is affected by periodontal disease.Aim: this study aimed to compare both GCF and salivary periostin levels during periodontal disease to their levels after non- surgical periodontal therapy.Subjects and methods: The present study was performed on a total of 30 subjects, 13 males and 17 females. The thirty selected participants were sampled at baseline and after receiving the non-surgical periodontal treatment.Results: In GCF, there was a statistically significant (at P ≤ 0.05) increase in mean Periostin level after treatment. While in saliva, there was a statistically significant (at P ≤0.05) decrease in mean Periostin level after treatment. Conclusion Our results suggested that GCF periostin level may be considered as a reliable marker in the evaluation of periodontal disease activity, while salivary periostin level could have a promising diagnostic potential. So, further investigations are recommended.
https://edj.journals.ekb.eg/article_72563_bc88798912f474267c449322404f6dd8.pdf
2019-04-01
1389
1395
10.21608/edj.2019.72563
Periostin
non-surgical periodontal treatment
saliva
gingival crevicular fluid
Amal
Hussien
1
Lecturer, Oral Medicine & Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.
AUTHOR
Amira
Maged
2
Associate Professor, Oral Medicine & Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.
AUTHOR
ORIGINAL_ARTICLE
Assessment of Idiopathic Osteosclerosis in The Jaws of The Egyptian Population Using Cone Beam Computed Tomography
Purpose: Idiopathic osteosclerosis is a common radiopaque lesion without clear cause that affects the mandible and maxilla. This study was conducted to assess the prevalence of idiopathic osteosclerosis in the jaws among Egyptian population.Subjects and Methods: 1100 CBCT scans were used to assess the prevalence, gender and age distribution, location, and size of idiopathic osteosclerosis.Results: Idiopathic osteosclerosis was found in 16.7% of the cases with equal distribution in males and females patients, especially, in the third decade. Mandibular lesions were found in 95.7% of them, 52.7% in molar region and 29.9 % in premolar region. The size ranged from 1.5 – 15.6 mm.Conclusion: Idiopathic osteosclerosis is not uncommon radiographic finding in Egyptian population with predilection to premolar-molar mandibular region.
https://edj.journals.ekb.eg/article_72564_401baca97bd1e0332d37c5c0db42dda3.pdf
2019-04-01
1397
1401
10.21608/edj.2019.72564
Idiopathic Osteosclerosis
Cone beam computed tomography
Egyptian
Mohamed
Zayet
1
Ass. Professor of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, Egypt
AUTHOR
Ahmed
Hassan
2
Ass. Lecturer of Oral Radiology, Faculty of Dentistry, El-Fayoum University
AUTHOR
ORIGINAL_ARTICLE
Volume Isotropic Turbo Spin Echo Acquisition Magnetic Resonance Imaging Pulse Sequence in Assessment of Temporomandibular Disorders
Background: Magnetic resonance imaging is the chief imaging modality used in assessment of temporomandibular disorders.Aim of the study: This study aimed to investigate the validity of Volume ISotropic Turbo spin echo Acquisition (VISTA) pulse sequence in the assessment of temporomandibular disorders.Subjects and Methods: Fifteen patients with temporomandibular joint related complaints performed MRI bilaterally using VISTA proton density and two-dimensional proton density turbo spin echo pulse sequences. Four-point scale was used to assess the clarity of articular disc position, disc morphology, cortical bone delineation, and overall image quality of both tested techniques. Besides, the final diagnosis of each case was obtained.Results: The main and standard deviation of traditionally used 2D proton density images in determination of disc position, disc morphology, delineation of cortical bone and overall image quality were (2.57± 0.49), (2.37± 0.60), (2.8± 0.4), (2.57± 0.49), respectively. While those for VISTA images were (1.8± 0.4), (1.53± 0.72), (2.1± 0.60), (1.7± 0.64) with the same order. The final diagnosis was similar in both techniques in 25 cases out of 30.Conclusion: Volume ISotropic Turbo Spin Echo Acquisition (VISTA) magnetic resonance pulse sequence could reveal the temporomandibular joint related structures, but with less image quality than that of traditionally used two-dimensional proton density images.
https://edj.journals.ekb.eg/article_72565_4c9bb9854cd31e24cc1f79c840222b01.pdf
2019-04-01
1403
1409
10.21608/edj.2019.72565
VISTA – pulse sequence – temporomandibular disorders
Mohamed
Zayet
1
Ass. Professor, Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University
AUTHOR
ORIGINAL_ARTICLE
PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT
Objectives: Our aim in the current study is to evaluate the level of high sensitivity C-reactive protein in serum of patients with periodontitis and type 2 diabetes before and after non-surgical periodontal treatment.Subjects and methods: 60 individuals in total with stage II grade A generalized periodontitis (n=20) and stage II grade B generalized periodontitis with type 2 diabetes (n=20) along with healthy control subjects (n=20) were enrolled in this study. Serum samples from all participants were obtained. Two serum samples, before & after non-surgical periodontal treatment, were gathered from patients with periodontitis and periodontitis with type 2 diabetes. Only one serum sample was collected from healthy controls. Enzyme linked immunosorbent assay technique (ELISA) was used to measure serum levels of high sensitivity C-reactive protein (hs-CRP).Results: The highest concentration of serum hs-CRP was detected in patients with periodontitis & type 2 diabetes. This is followed by periodontitis group and then controls subjects. A statistical significant reduction in the hs-CRP serum levels after non-surgical periodontal treatment was detected in periodontitis with diabetes group while the periodontitis group showed similar reduction but without statistical significance. High diagnostic accuracy of serum hs-CRP was revealed by the Receiver Operating Characteristic (ROC) curve analysis, especially when comparing periodontitis patients, with or without diabetes, with the control.Conclusions: Serum hs-CRP could be utilized as a prognostic marker in patients with periodontitis and type 2 diabetes.
https://edj.journals.ekb.eg/article_72566_7b148c88db9883f935a11dd87c344a1a.pdf
2019-04-01
1411
1419
10.21608/edj.2019.72566
Periodontitis
Type 2 Diabetes
serum high sensitivity C-reactive protein
non-surgical periodontal therapy
Nayroz
Tarrad
1
Lecturer, Department of Oral diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University, Egypt
AUTHOR
Sandy
Hassan
2
Lecturer, Department of Oral diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University, Egypt
AUTHOR
Gihane
Madkour
3
Associate Professor, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt
AUTHOR
Olfat
Shaker
4
Professor, Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt
AUTHOR