Evaluation of Salivary versus Serum Squamous Cell Carcinoma Antigen in Oral lichen Planus

Document Type : Original Article

Authors

1 Lecturer of Oral Diagnosis, Oral Medicine, and Periodontology, Beni-Suef university, Egypt.

2 Department of Oral Pathology, Faculty of Dentistry Beni-Suef university, Egypt

3 Department of Biochemistry, Faculty of Medicine, Cairo University

4 Oral Medicine and Periodontology Faculty of Oral and Dental Medicine Cairo University

Abstract

Background and Objectives: Oral Lichen Planus is a chronic, inflammatory, immune mediated disease affecting the oral cavity. It is the oral variant of the mucocutaneous disease lichen Planus. The pathogenesis of OLP has been deeply studied yet not totally clear, this prospective case control study aimed to evaluate squamous cell carcinoma antigen in serum and saliva of Oral lichen planus.
Methods: 30 individuals were included in the study; oral lichen planus and healthy volunteers. Serum and salivary samples were collected from patients and volunteers. Pain score was performed using Visual Analogue Scale Thongprasom sign scoring for OLP was used to record the cases clinically; Oral lichen planus diagnosis was confirmed by histopathology. A double-antibody sandwich enzyme-linked immunosorbent assay was used to assay the level of Human squamous cell carcinoma antigen in samples.
Results: Both SccAg in serum and saliva showed statistically significantly higher mean levels than control group. ROC curve analysis of the two markers showed 100 % diagnostic accuracy on differentiation from control group at cut-off values of 2.6 and 1.5 ng/ml for Scc Ag in serum and saliva, respectively.
Conclusion: Salivary SccAg can be considered as a significant diagnostic test for OLP disease activity.

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