Adjunctive effect of Vit D to local cortisone in treating oral lichen planus lesions in menopausal and post- menopausal Egyptian women.

This study was conducted to evaluate the effect of Vitamin D (Vit D) supplementation to topical corticosteroids in the treatment of oral lichen planus (OLP) among postmenopausal women. Thirty post-menopaus‌al women, their ages ranging between 45-65 years, diagnosed with any form of Oral lichen planus and presenting with serum 25 Hydroxyvitamin D levels below 30ng/ ml were randomly allocated into one of two groups (15 patients each) and treated as follows: The control group I, received topical cortisone alone; The experimental group II, who were treated with topical cortisone supplemented with Vit D every week for one month. Serum level of TNF-α, clinical and pain scores were carried out at the time of the initial visit and at 2, 4, and 6 weeks. Results showed improvement in clinical score. Both treatment modalities resulted in a statistically significant decrease in pain score, and TNF- α (P < 0.001) compared to the baseline values. There was no statistically significant difference between the two groups (P > 0.05) at any evaluation period for the pain score, while TNF- α showed statistically significant differences at 4 weeks only in favor to group II (P < 0.05).
Conclusion: Within the limitation of this study, it can be concluded that Vit D supplementation to conventional therapy can help in treating OLP among post-menopausal women. Attention must be given to educate the women in this critical age to pay attention to Vit D deficiency to avoid such serious diseases.