Mechanical Properties and Fluoride Release of Glass Ionomer Cement with Enhanced Antimicrobial Activity Derived from Addition of Schiff Base of Tetronic 1107

Document Type : Original Article

Authors

1 Biomaterials Department, Faculty of Dentistry, Tanta University

2 Chemistry Department, Faculty of Science, Tanta University

3 Department of Chemistry, Faculty of Science, Tanta University

4 Department of Microbiology (Mycology), Faculty of Science, Tanta University

Abstract

Abstract:
Objectives: To synthesize and characterize Schiff base of Tetronic 1107 (T1107SB) to be added to GIC powder to enhance its antimicrobial activities and to evaluate the compressive strength (CS), elastic modulus (E), Vickers microhardness (HV) and fluoride release (FR) of the synthesized GIC.
Materials and methods: T1107SB was synthesized by chloroacetylation of T1107, amination of chloroacetylated T1107 and modification of aminated T1107 with vanillin. Characterization of T1107SB was carried out by Fourier transform infra-red spectroscopy (FTIR), Elemental micro-analysis and Thermal gravimetric analysis (TGA). Antimicrobial activity of T1107SB-modified GIC (T-GIC) was studied by the "cut plug method" and minimal inhibitory concentration (MIC) test. CS and E were investigated in a universal testing machine according to the ISO 9917:2007. HV was evaluated by a Digital Microhardness Tester. Fluoride levels in ppm were obtained using the ion-selective electrode method. A one-way ANOVA and Bonferroni test were used to analyze the data (p ≤ 0.05).
Results: Synthesis of T1107SB was confirmed by FTIR, elemental micro-analysis and TGA. T-GICs exhibited an enhanced antibacterial activity against Staphylococcus aureus and Bacillus cereus as confirmed by the growth inhibition zones. T-GICs showed no improvement in the antimicrobial activity against Candida albicans, compared to C-GIC. Significant differences were found between studied groups in CS, E, HV and FR. Increasing the percent of T1107SB resulted in a systematic reduction these properties.
Conclusions: Addition of T1107SB is promising in enhancing the antibacterial activity of GIC materials without deteriorating their mechanical and fluoride-releasing properties.

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