Clinical Evaluation Of The Efficiency of Intralesional Injection Of Autologous Platelet Rich Plasma In Treatment Of Erosive Oral Lichen planus.

Document Type : Original Article

Authors

1 Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Galala University, Egypt.

2 Lecturer of Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Egypt.

Abstract

Objectives:
Oral lichen planus could be a doubtless malignant autoimmune disease, characterized by burning and pain that reduces the standard of patient's life. Treatment of OLP remains a significant challenge despite the recent advances in understanding the immunopathogenesis. The properties of Platelet-rich plasma suggested its application in clinical practice for treatment of OLP patients that do not respond to conventional therapy. This study aims to evaluate the effectiveness of intralesional Platelet rich Plasma in treatment of Erosive lichen planus.
Materials and methods: The study sample consisted of 10 patients of erosive OLP among which were given intralesional PRP. All the patients were given weekly injections for 4 weeks. The two fundamentals variables used for assessment of the patient is pain control and healing of the lesion. Each visit consists of measuring the target lesion size and pain evaluation by Visual analogue scale (VAS) .
Results: No serious adverse reaction was obtained in patients during the 4 weeks of treatment. The result was satisfactory with a significant reduction in patient symptoms. Reduction in terms of size and inflammation was observed.
Conclusion: This methodology of using intralesional PRP showed to be effective in decreasing the symptoms and improvement in clinical signs of OLP, which was resistant to conventional therapy.
Key words: intralesional PRP, Erosive OLP, potentially malignant

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