Reosseointegration of bone defect surrounding dental implant associated with periimplantitis using Nanobone with or without simvastatin: A six month randomised controlled clinical trial.

Document Type : Original Article

Author

Lecturer of Oral Medicine , Periodontoloy and Oral DiagnosisŲŒ Faculty of Dentistry, South Valley University

Abstract

Abstract:
Objectives: The aim of the study was evaluating the effect of adding simvastatin to synthetic bone substitute on the regenerative surgical treatment of bone defects associated with periimplantitis in a six months randomized controlled clinical trial.
Material & Methods: 30 patients diagnosed with periimplantitis divided in two groups, group I treated by using synthetic bone substitute (Nanobone), group II treated by using Nanobone with simvastatin. Clinical evaluation was the measurements for probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), modified sulcus bleeding index (mSBI) and mucosal recession. Radiographic bone fill was evaluated at baseline and after six months.
Results: The results for both treatment groups showed significant reductions obtained in the mean PPD, CAL and mSBI at six months postoperatively when compared to baseline values , on the other-side no statistically significant difference was observed for the mean PI and MR. The mean of bon fill in group II was better than that of group I and this results was statistically significant (P < 0.05).
Conclusions: The two regenerative approaches produced significant improvements in both clinical and radiographic assessments, but adding simvastatin to Nanobone produce better results in terms of bone fill.

Keywords

Egyptian Dental Journal
Volume 67, Issue 2 - Serial Number 3
April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
April 2021
Pages 1241-1250

Files

Share

How to cite

Statistics