Comparative Assessment of remineralizing potential of recent biomimetic remineralizing agents on sub-surface carious lesions: An in vitro study

Introduction: Enamel demineralization and remineralization are considered dynamic and continuous process that occurs throughout the life. Subsurface caries is distinct when the amount of subsurface minerals missed go above the amount of minerals secured. The biomimetic remineralizing protocol is planned to encourage maximum maintenance of healthy dental hard tissues in subsurface stage.
Aim: Directed to assess the remineralizing potential of self-assembling peptide P11-4, phosphorylated chitosan and nano hydroxyapatite paste on subsurface carious lesions.
Materials and methods: Forty sound non-carious human anterior teeth were used. The teeth were divided into four groups (10 teeth each). Group A1: control; Group A2: using Curodont repair; Group A3 using phosphorylated chitosan and; Group A4: using nanohydroxyapatite paste. All products were applied according to the manufacturer's instructions and each group was subdivided into two groups according to the storage time group B1: 3 months and group B2: 6 months.
Calcium and phosphorous weight and ratio were assessed using dispersive X-ray energy and Diagnodent pen at base line then after 3and 6months. The mean and standard deviation values were calculated for each group in each test.
Results: Specimens treated with Curodont repair after six months record the highest mean value while the lowest mean value was found in artificial saliva, also for all remineralizing agents (Curodont repair, phosphorylated chitosan, and Nanohydroxyapatite paste) and control group the remineralization potential was increased by increasing the storage time (three month and six months).
Conclusion: Curodont repair is considered a valuable biomimetic remineralizing agent.
Keywords: Remineralization, Chitosan, self-assemblingpeptideP11-4, Nanohydroxyapatite paste.