The effect of Erbium:YAG Laser for the Fibronectin Expression in Gingival Epithelium with Nifedipine induced Gingival Overgrowth

Document Type : Original Article

Authors

1 Lecturer, Oral Medicine and Periodontology Department , Faculty of Dentistry Cairo University, Cairo, Egypt. Oral Medicine and Periodontology Department, Faculty of Dentistry Badr University in Cairo, (BUC), Cairo, Egypt.

2 Lecturer, Oral medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine Beni-Suef University.

Abstract

Gingival overgrowth is one of the side-
effects seen as a result of the regular administration of the
calcium channel blocker anti-hypertensive drug Nifedipine.
Fibronectin (FN), is an adhesive high molecular weight extra
cellular matrix glycoprotein which plays an important role in
influencing cell growth, adhesion, migration as well as
extracellular matrix organization. It also contributes to
fibroblast attachment and proliferation, and participates in
the regulation of tissue fibrosis. Erbium: YAG laser was
approved in 1997 by the U.S. Food and Drug Administration
for hard and soft tissue treatment in dentistry. Several studies
have been published to demonstrate its efficacy for bone
cutting, plaque and subgingival calculus removal, as well as
having an antiseptic effect on both soft and hard periodontal
tissues. Conventional scaling in combination with Erbium:
YAG laser has unexpectedly showed complete healing with

(2

normalization of the gingiva, making further surgical
treatment for gingival volume reduction unecessary.

Keywords

Egyptian Dental Journal
Volume 67, Issue 4 - Serial Number 3
October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
October 2021
Pages 3259-3269

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