The Effectiveness of Placental Extract Gel in the Treatment of Recurrent Aphthous Stomatitis: Randomized Clinical

Document Type : Original Article

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Lecturer of Oral Medicine and Periodontology, Suez Canal University.

Abstract

Abstract:
Background: The most frequent oral ulcer that affects non keratinized oral mucosa is recurrent Aphthous stomatitis (RAS). The goal of the current investigation was to determine the effectiveness of the topical application of placental extract gel (PEG) in the treatment of RAS.
Materials and methods: 40 patients with RAS participated in this research. They were randomly allocated into two groups. Group I (control): include 20 patients treated with topical application of benzydamine hydrochloride gel and group II (test group) include 20 patients treated with topical application of placental extract gel. The effectiveness of the treatment modalities was assessed by measuring pain intensity, ulcer size at baseline, 3rd day and 7th day.
Results: both treated groups showed a statistically significant decrease (P≤ 0.001) in pain intensity and ulcer size at days 3 and 7 compared to baseline data. However, the RAS treated with PEG showed statistical significant decrease (P≤ 0.001) in pain intensity and ulcer size at days 3 and 7 compared to the control group.
Conclusion: Topical PEG is an effective topical agent in RAS treatment, which enhances the patient's normal activities and daily life events.

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Egyptian Dental Journal
Volume 68, Issue 3 - Serial Number 3
Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
July 2022
Pages 2255-2263

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