Impact of Hyaluronic acid on healing of tongue ulcers in diabetic rats

Document Type : Original Article

Authors

1 Department of Oral Biology, Faculty of Dentistry, Mansoura University Department of Maxillofacial Surgery and Diagnostic Science, Faculty of Dentistry, Majmaah University. Saudi Arabia.

2 Department of Oral Biology, Faculty of Dentistry, Mansoura University Department of Basic Dental& Medical sciences, Faculty of Dentistry, Ha’il University.

Abstract

Introduction: Wound healing is a highly complicated process achieved through definitely programmed stages. Hyaluronic acid is a natural component present essentially in the skin and other connective tissues, it has been used in many medical fields for acceleration of wound healing.
Aim: This study aimed to investigate the therapeutic effect of hyaluronic acid on healing of tongue ulcer in diabetic rat model.
Material & Methods: Thirty male Albino rats were subjected to diabetes induction and after 1 week the animals were classified into 3 groups, Group I: rats were subjected to tongue ulcer and did not receive any treatment. Group II: rats were subjected to tongue ulcer and the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid. Group III: rats were received 1-2 IU/ g/day of insulin NPH injected subcutaneous and then subjected to tongue ulcer after one week from the starting of insulin injection. The animals were sacrificed at 4 and 10 days after ulcer induction, specimens were prepared for histological examination and immunohistochemical staining for α-SMA.
Results: Histological examination revealed better enhancement of ulcer healing and re-epithelization together with reorganization of the epithelium and connective tissue in group II and III samples when compared to group I after 4 and 10 days of ulcer induction.
Conclusion: oral application of hyaluronic acid gel has beneficial effects in accelerating wound healing and improving all phases of wound repair in tongue ulcers in rats.

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Egyptian Dental Journal
Volume 68, Issue 3 - Serial Number 3
Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
July 2022
Pages 2409-2418

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