Botilinium Toxin Injection, A Potentially Effective Method For Preventing Implant Failure In Patients With Bruxism

Document Type : Original Article


1 Department of Removable Prosthodontics, Faculty of Dentistry, British University, Cairo, Egypt

2 Department of Pharmacology, Faculty of Dentistry, British University, Cairo, Egypt. Director of Stem Cells and Tissue Culture Hub, Centre of Innovative Dental Sciences (CIDS), Faculty of Dentistry, British University, Cairo, Egypt.


Purpose: Decreasing bone loss around implants is an important factor for implant durability. Pathological forces, such as bruxism, may result in bone loss and eventual implant failure. The aim of this study was to investigate the effect of botulinum toxin injection on biting forces, and its ultimate effect on peri-implant bone changes at different time intervals. Materials and methods: A randomized clinical trial including 20 females (45-60 years old). All patients received an implant-supported partial denture. Patients were divided into 2 groups: 1. control group (CTR) (no injection), and 2. Botox group (BTX) (injected with botulinium toxin in their masseter muscle). T-scan was used for occlusal analysis (biting force), and was carried out at denture insertion after 2 weeks, 3 months and 6 months of insertion. CBCT was used to detect peri-implant bone changes, and was performed at insertion, 3 months, 6 months and 1 year after insertion. Results were analyzed via two-way (ANOVA) to compare between groups at different time periods, followed by Bonferroni's test post-hoc analysis. Results: T-scan analysis and CBCT imaging showed that the biting force mean values and the mean crestal bone level changes in the BTX group were significantly lower than that of the control group.Conclusions: Botox injection in the masseter muscle bilaterally for bruxer patients with edentulous areas would offer them a viable chance for implants as a treatment option.


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