THE PROLIFERATIVE EFFECT OF CURCUMIN NANO PARTICLES ON RADIATED PAROTID GLANDS OF ALBINO RATS

Document Type : Original Article

Authors

1 Oral Biology Department Faculty of Dentistry Benisuef University Benisuef Egypt

2 Oral Biology Department, Faculty of Dentistry, Minia University Minia, Egypt

Abstract

Abstract
Objectives: Xerostomia, which occurs early in the course of radiation, causes a decrease in salivary flow rate. The time it takes for a patient's salivary function to become diminished varies. The salivary glands go through a variety of histological alterations.
Aim: The goal of this study was to explore how curcumin nanoparticles affected cellular proliferation after radiotherapy. Curcumin nanoparticles are an anti-oxidant material that has been used to treat the histopathological alterations caused by radiation therapy in the parotid glands of albino rats. Materials and methods: The researchers used 45 adult male Albino rats, 15 for the control group, 15 for the radiated group, and 15 for the curcumin nanoparticle group. The parotid glands were dissected and histological and immunohistochemical examinations were performed. Result: Curcumin nanoparticles have a proliferative action that restores atrophied radiated parotid glands, according to histological and immunohistochemistry data. Conclusion: Curcumin nanoparticles have been shown to be a proliferative and anti-oxidant substrate in the treatment of histological abnormalities in albino rats radiated parotid glands. Keywords: radiotherapy; curcumin; nanoparticles; PCNA; Parotid Glands.

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Egyptian Dental Journal
Volume 68, Issue 4 - Serial Number 3
October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
October 2022
Pages 3237-3246

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