THE ANTIBACTERIAL EFFECT OF CYSTEAMINE AND ITS COMBINATIONS WITH VARIOUS INTRACANAL MEDICATIONS AGAINST ENTEROCOCCUS FAECALIS

Document Type : Original Article

Authors

1 B.D.S., Faculty of Dentistry, Ain Shams University

2 Professor of Endodontics, Endodontic Department, Faculty of Dentistry, Ain Shams University

3 Lecturer in Endodontics, Endodontic Dep., Faculty of dentistry, Ainshams Univ.

Abstract

Background: The microbiological ecosystem is considered the main obstacle in endodontics. Therefore, canal disinfection became a great priority.
Aim of the study: This study was established to assess cysteamine’s antibacterial effect against E. Faecalis and compare the improvement effect to its combination with various intracanal medicaments.
Methods and Materials: Cleaning and shaping were performed on human single-rooted teeth then inoculated by E. faecalis biofilm. Samples were divided randomly into three groups: Group I to verify the maturation of E. faecalis biofilm inside the root canal using SEM. Group II were divided into four subgroups according to the intracanal medication used. Subgroup A was treated with Cysteamine. Subgroup B was treated with Chlorhexidine Cysteamine combination. Subgroup C was treated with Calcium hydroxide (CaOH) Cysteamine combination. Subgroup D was treated with Triple antibiotic paste Cysteamine combination. Group III were divided into two subgroups treated with plain gel; positive control and negative control. Samples collected from root canals were used for viable count (CFU/ml). Log transformation of the data was carried out. The statistical significance level was set at P < 0.05.
Results: There was a significant difference between different groups (p < 0.001). Post hoc pairwise comparisons showed statistically significant difference between subgroups except for the CaOH Cysteamine combination subgroup and TAP Cysteamine combination subgroup.
Conclusion: Cysteamine usage provides a synergistic antibacterial effect with other intracanal medications. CHX Cysteamine combination was the most effective antibacterial drug that provided effectiveness against E. faecalis.

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Egyptian Dental Journal
Volume 68, Issue 4 - Serial Number 5
October (Conservative Dentistry and Endodontics)
October 2022
Pages 3869-3879

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