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Egyptian Dental Journal
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Volume Volume 69 (2023)
Issue Issue 1
Issue 1 - January (Orthodontics, Pediatric & Preventive Dentistry)
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January (Oral Surgery)
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January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
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Volume Volume 68 (2022)
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abdelkader, A., mohamed, D., Baraka, N. (2023). “The Effect of Diabetes Induction in Pregnant Rats on Molar Root Formation of Offsprings” “Histological and Immuno-histochemical study”. Egyptian Dental Journal, 69(1), 301-310. doi: 10.21608/edj.2023.168491.2290
alaa abdelkader; daila ghazy mohamed; Nuha Baraka. "“The Effect of Diabetes Induction in Pregnant Rats on Molar Root Formation of Offsprings” “Histological and Immuno-histochemical study”". Egyptian Dental Journal, 69, 1, 2023, 301-310. doi: 10.21608/edj.2023.168491.2290
abdelkader, A., mohamed, D., Baraka, N. (2023). '“The Effect of Diabetes Induction in Pregnant Rats on Molar Root Formation of Offsprings” “Histological and Immuno-histochemical study”', Egyptian Dental Journal, 69(1), pp. 301-310. doi: 10.21608/edj.2023.168491.2290
abdelkader, A., mohamed, D., Baraka, N. “The Effect of Diabetes Induction in Pregnant Rats on Molar Root Formation of Offsprings” “Histological and Immuno-histochemical study”. Egyptian Dental Journal, 2023; 69(1): 301-310. doi: 10.21608/edj.2023.168491.2290

“The Effect of Diabetes Induction in Pregnant Rats on Molar Root Formation of Offsprings” “Histological and Immuno-histochemical study”

Article 13, Volume 69, Issue 1 - Serial Number 3, January 2023, Page 301-310  XML PDF (2.9 MB)
Document Type: Original Article
DOI: 10.21608/edj.2023.168491.2290
Authors
alaa abdelkader email orcid 1; daila ghazy mohamedorcid 2; Nuha Barakaorcid 3
1Demonstrator of Oral Biology, Faculty of Dentistry, Al-Ahram Canadian University.
2Assistant Professor of Oral Biology Faculty of Dentistry, Ain Shams University
3Lecturer of Oral Biology, Faculty of Dentistry, Ain Shams University
Abstract
ABSTRACT
OBJECTIVE: Diabetes mellitus (DM) as a chronic disease has multiple effects upon both general and oral health. This study aimed to evaluate the effect of DM in pregnant rats on root formation of their offspring.
METHODOLOGY: This investigation was carried out on forty-two Albino rats. Rats were divided into two groups(n=21): group C (control): offspring to mothers injected by intraperitoneal single dose of 1ml Citrate buffer, group E (diabetic): offspring born to mothers rendered diabetic through single intraperitoneal injection of Streptozotocin (40mg/kg body weight) dissolved in 1ml Citrate buffer. Their offspring were sacrificed one, two and four weeks after birth (E1, E2 and E3 subgroups respectively). The lower jaws of the offspring were excised and processed for histological and immunohistochemical investigation of osteopontin (OPN) antibody marker.
RESULTS: Diabetic rats of E1 subgroup showed apparently thin epithelial diaphragm. E2 subgroup showed areas of degeneration between odontoblastic cells and periodontal fibers disorganization, while E3 subgroup showed increased cementum thickness, widening of cementocytes lacunae and massive congestion in pulpal blood vessels. Positive OPN immunoreactivity was observed in E1 subgroup in the epithelial diaphragm cells and primitive pulp tissue while E2 and E3 subgroups showed immunoreactivity in pulp, cementoblastic cells lining the cementum tissue and PDL fibers.
CONCLUSIONS: Diabetes mellitus induction in pregnant mothers adversely affected molars root formation of the offspring. Alterations in dental root forming cells, pulp, cementum and PDL in the offspring were associated with increased OPN immuno-expression.
Keywords
Diabetes Mellitus; offspring; root formation; osteopontin
Main Subjects
Oral Biology
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