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Egyptian Dental Journal
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Volume Volume 69 (2023)
Issue Issue 1
Issue 1 - January (Orthodontics, Pediatric & Preventive Dentistry)
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January (Oral Surgery)
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January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
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Volume Volume 68 (2022)
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Labah, D., wahba, O. (2023). POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY). Egyptian Dental Journal, 69(1), 371-381. doi: 10.21608/edj.2022.171428.2328
Doaa A Labah; omneya wahba. "POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY)". Egyptian Dental Journal, 69, 1, 2023, 371-381. doi: 10.21608/edj.2022.171428.2328
Labah, D., wahba, O. (2023). 'POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY)', Egyptian Dental Journal, 69(1), pp. 371-381. doi: 10.21608/edj.2022.171428.2328
Labah, D., wahba, O. POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY). Egyptian Dental Journal, 2023; 69(1): 371-381. doi: 10.21608/edj.2022.171428.2328

POTENTIAL EFFECT OF PLATELET RICH PLASMA AS A PROMOTER OF BONE HEALING IN OBESE RATS (HISTOLOGICAL AND ULTRASTRUCTURAL STUDY)

Article 19, Volume 69, Issue 1 - Serial Number 3, January 2023, Page 371-381  XML PDF (3.27 MB)
Document Type: Original Article
DOI: 10.21608/edj.2022.171428.2328
Authors
Doaa A Labahorcid 1; omneya wahba email orcid 2
1Oral Biology Department, Faculty of Dentistry, Zagazig University, Zagazig, Egypt
2Oral Pathology Department, Faculty of Oral and Dental Surgery, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
Abstract
The study aimed to examine the impact of platelet rich plasma (PRP) on the healing of a mandibular bone defect in obese rats. In this research, forty-eight adult male albino rats were divided into two equal groups; Group 1: were fed on standard diet. Group 2: were fed on high fat diet for four weeks for obesity inducing. A bone defect on the right side of mandible was created in each rat then all rats were subdivided into two equal subgroups. In subgroups 1.1 and 2.1, the bone defects were left without treating whereas in subgroups 1.2 and 2.2 the bone defects were filled with PRP. Two and four weeks postoperatively, six rats per group were euthanized and the samples were processed histological examination, X-ray elemental microanalysis and scanning electron microscopic examination. The results showed that rats received high fat diet and their bone defects left untreated revealed delayed bone healing and depicted significant decrease in bone calcium level in comparison with other subgroups. Interestingly, rats received high fat diet and their bone defects filled with platelet rich plasma revealed marked progress in bone healing and exhibited significant increase in bone calcium level in comparison with rats received high fat diet and with untreated bone defect. Conclusion: Obesity impaired the healing of mandibular bone defect. However, PRP has the ability to offset the negative effect of obesity and promote bone healing in obese rats. Therefore, it is highly recommended in obese individuals to fill the surgical bone defects with PRP.
Keywords
Bone healing; Obesity; Platelet rich plasma
Main Subjects
Oral Biology
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