The Use of Human Placental Extract to Arrest and Restrict the Established Carious Lesions with the Aid of Nano Fibered Local Drug Delivery Systems: A Two Years' Evidence Based Study

Document Type : Original Article

Authors

1 Associate Professor of Operative and Cosmetic Dentistry, Faculty of Oral and Dental Medicine Pharohs University, Egypt.

2 Assistant Professor of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Egypt

Abstract

In this study we made use of these unique properties of the human placental extract in order to cause arrest of the established carious lesions.A treatment aiming at tissue healing ,regeneration and thus dentinogenesis.Local drug delivery systems were used to aid in sustained,controlled and targeted release of the placental extract .Eighty patients were included in this study .The patients were divided into two groups of 40.Group (P)received the placental extract treatment and was further divided into two sub groups of 20 (Pa&Pb) according to the method of administration of the placental extract and the pharmaceutical modulation of the release and targeting process. The other group (C)was a control group and did not receive the placental extract treatment . After two weeks all patients were investigated clinically for signs and symptoms and radiographically for pathologic radiographic changes .Follow up of all patients was carried out over three and six months and two years time. Regarding group (P),sub group (Pa) ,except for one case, at all time periods ,nineteen cases demonstrated appropriate function and normal periodontium apparatus and total absence of any clinical signs and symptoms .The same went with sub group (Pb) except for two cases .Regarding the control group (C),at all time periods ,twenty one cases did not show any clinical signs symptoms and demonstrated normal periodontium apparatus .Five cases failed over six months and needed retreatment .Nine cases failed in two years and needed retreatment .While five cases failed in two years and needed traditional endodontic treatment .

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Egyptian Dental Journal
Volume 69, Issue 1 - Serial Number 5
January (Conservative Dentistry and Endodontics)
January 2023
Pages 855-867

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