Evaluation of the Efficacy of Flowable Leukocyte and Platelet–Rich Fibrin versus Hyaluronic Acid as Bioactive Implant Coatings (Randomized Controlled Clinical Trial)

Document Type : Original Article

Authors

1 Associate Professor of Periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University, Egypt

2 B.D.S, clinical master of oral implantology , Faculty of Dentistry Alexandria University, Egypt

3 Professor of Periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry Alexandria University, Egypt

Abstract

Background: osseointegrated dental implants are often left load-free during the healing period. Many trials have been conducted to improve osteointegration to minimize loading time and ultimately raise patient satisfaction.
Aim of the Study: to assess the effectiveness of flowable L-PRF and hyaluronic acid as bioactive coatings for dental implants, to decrease loading time.
Material and Methods: 30 sites indicated for implant placement in the mandibular posterior region were selected and divided into 3 groups. In test group I; 10 implants were coated with flowable L-PRF and in test group II; 10 implants were coated with Hyaluronic acid while in the negative control (group III) the remaining 10 implants were left uncoated. After osteotomy; all implants were installed. Clinical assessment of implant stability was carried out immediately post-insertion (primary stability) and then 2 and 3 months post-insertion (secondary stability) using Resonance Frequency Analysis. Radiographic assessment of marginal bone level was evaluated immediately post insertion and 3 months later before loading.
Results: The results of this study revealed that implants coated with flowable L-PRF showed less marginal bone loss than those coated with hyaluronic acid or the uncoated ones (median of marginal bone loss at 3rd-month post insertion was 0.35mm, 0.37mm and 0.51mm respectively). On the other hand, implants coated with HA showed better secondary stability at 3rd-month post insertion with a median of (89.50) compared to (82.50) for flowable PRF and (79.00) for the uncoated control group.
Conclusion: bioactive implant coatings can enhance osseointegration and decrease loading time.

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Egyptian Dental Journal
Volume 70, Issue 2 - Serial Number 3
April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
April 2024
Pages 1339-1353

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