Document Type : Original Article


1 Faculty of Dental Medicine for Girls, Al- Azhar University, Cairo, Egypt.

2 Faculty of Dentistry, Al-Ahliyya Amman University, Jordan. Faculty of Dentistry, Alexandria University, Egypt.

3 Faculty of Dentistry, Assiut University. Dental College, City University Ajman, Ajman, UAE.

4 Faculty of Dentistry, Alexandria University, Egypt. Faculty of Medicine, Mansoura University, Egypt.

5 Faculty of oral and dental medicine, Ahram Canadian University.

6 Faculty of Dentistry, Fayoum University, Cairo, Egypt


Objective: The study aimed to assess histologically and histomorphometrically the antiosteoporotic outcome of Fosamax and Klimadynon (black cohosh) in osteoporotic albino rats during tooth eruption. Methods: 12 female albino rats were divided into 4 equal groups: Negative Control group, Osteoporotic group: animals were injected by methyl-prednisolone subcutaneously for two months. Fosamax group: osteoporotic rats were treated simultaneously with oral Fosamax. Klimadynon group: osteoporotic rats were treated simultaneously with oral klimadynon. Pregnancy and delivery occurred during experiment, 40 offspring rats were divided into 4 equal groups, labelled from I to IV, each group was related to its corresponding mother' s group. Five rats from each offspring group were sacrificed at 7 and 14 days after their birth, the mandibles dissected and prepared for histopathological evaluation. Results: significant wearing away of the bone and diminution in the thickness of bone trabeculae were spotted in Group II in analogy to the control one. Group III showed remarkable improvement of the bone thickness over the erupting molars. While in group IV, the alveolar bone trbeculae were thin in structure. The highest mean values of bone thickness at 7 & 14 days were evident in the Fosamax group. Conclusion: The remarkable bone loss induced by Glucocorticoids could be compensated by Fosamax. Since black cohosh is a natural product, it is it is proposed to be used as a to be used as a favourable osteoprotective medication, however, it could cause delay in eruption but in a lesser degree than Fosamax.


Main Subjects