Colocalization of VEGF and iNOS in Parenchymal and Stromal Cells of Oral Squamous Cell Carcinoma

Document Type : Original Article

Author

Assistant Professor, Oral Pathology Department, Faculty of Dentistry, Tanta University, Egypt, Assistant Professor of Oral Pathology, Department of Biomedical and Dental Sciences, Faculty of Dentistry, Al-Baha University, Al-Baha, Saudi Arabia

Abstract

Background and objectives: Tumor angiogenesis and inflammation terms are intricately linked to cancer progression. Vascular endothelial growth factor (VEGF), which controls special occasions in angiogenesis of pathological conditions that are involved in the metabolic functions of cancer cells, is examined in conjunction with the inflammatory cytokine inducible nitric oxide synthase (iNOS) in parenchymal together with stromal cells of oral squamous cell carcinoma (OSCC) as well as assessing microvessel density (MVD). Methods: Immunohistochemistry will be applied to analyze the appearance of VEGF, iNOS as well as CD31 within 31 OSCCs paraffin blocks, which comprised of 13 well differentiated, 10 moderately differentiated, and 8 poorly differentiated (paraffin blocks OSCC). Results: Both VEGF and iNOS exhibit strong expression in both parenchymal and stromal cells in all grades of OSCC together with increased MVD. Conclusion: The discriminating expression of VEGF and iNOS from well to poorly differentiated OSCC potentially correlates with its increased invasiveness.

Key words: VEGF, iNOS, parenchymal, stromal, OSCC

Keywords

Main Subjects

Egyptian Dental Journal
Volume 70, Issue 3 - Serial Number 3
July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
July 2024
Pages 2305-2311

Files

Share

How to cite

Statistics