Evaluation of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) salivary levels in Oral Lichen Planus patients, Diabetics, and Diabetics with Oral Lichen Planus

Document Type : Original Article

Authors

1 Lecturer at Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt

2 Professor at Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt

3 Researcher at Department of Basic Dental Science, Oral and Dental Research Institute, National Research Centre,Giza, and Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Galala University, Suez, Egypt

Abstract

Background: Oral lichen planus (OLP) is an autoimmune chronic muco-cutaneous disease that greatly affects the quality of life of LP patients with a progressive rate of malignant transformation. Diabetes Mellitus (DM) is assumed to be a globally affecting metabolic disorder that is exceedingly rising with a disturbing rate. Studies focusing on the association between LP and DM are still inconsistent. Objectives: This study aimed to analyze and compare the salivary levels of antioxidants GPx & SOD in the four groups of OLP, DM, OLP with DM and the healthy control, and to establish a correlation between the association of oral lichen planus with diabetes. Materials and method: 44 subjects were enrolled in this prospective cohort study. The patients were divided into four groups, 11 in each group: healthy control patients (group A), OLP (group B), DM (group C) and OLP with DM (group D). The salivary levels of antioxidants GPx &SOD were analyzed and compared to establish a correlation between the association of OLP with DM. Results: The mean GPx levels were highest in group A ,then, group C followed by group B, while group D had the lowest mean GPx level. The mean SOD levels were highest in group A followed by group C then group B while group D had the lowest mean SOD levels with insignificant difference between them. Conclusion:. Antioxidants play a vital role in human body, with a relationship existing between oxidative stress, hyperglycemia and cellular dysfunction.

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Egyptian Dental Journal
Volume 70, Issue 4 - Serial Number 3
October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
October 2024
Pages 3267-3280

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