Biochemical effect of locally delivered tea tree oil gel as an adjunct to non-surgical periodontal therapy: A Randomized Controlled Trial

Document Type : Original Article

Authors

1 Lecturer of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt

2 Professor at Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

3 Assistant Lecturer at Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Misr International University, Cairo, Egypt.

Abstract

Objective: This study's main objective was to assess the therapeutic benefits of using Tea Tree Oil (TTO) gel intrapocket as a supplement to non-surgical periodontal therapy.
Methods and materials: A three-month, double-blind, randomized, controlled biochemical trial including 22 individuals with Stage III Grade B periodontitis was carried out. Randomly selected patients were allocated to two treatment groups: group I received NSPT plus locally applied TTO gel at the site of the deepest probing pocket depths (PPD); group II received NSPT alone. At 0 and 90 days after treatment, GCF samples were collected for biochemical analysis for Tumor Necrosis Factor Alpha (TNF -α), as well as Oral Health Impact Profile (OHIP-14) questionnaire.
Results: The outcomes demonstrated that, in comparison to the baseline, both groups' metrics had improved. The test group showed a much greater decrease in TNF-α level. Patients in both groups expressed the same degree of satisfaction.
Conclusion: Tea tree oil gel may be more effective at reducing periodontal inflammation when used in conjunction with non-surgical periodontal therapy.
Keywords: Nonsurgical periodontal treatment, Periodontitis, Tea tree oil, Local Drug Delivery.

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Egyptian Dental Journal
Volume 71, Issue 1 - Serial Number 3
January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
January 2025
Pages 411-418

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