Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3

Document Type : Original Article

Authors

1 Associate Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University

2 Associate Professor of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ain Shams University

3 Associate Professor of Oral Pathology, Faculty of Dentistry, Ain Shams University

Abstract

Purpose of the study: Evaluating the influence of combination of vitamin D3 with particulate bovine xenograft when placed in post-extraction sockets on the newly formed bone quality.
Primary outcome: Implant primary stability
Secondary outcomes: Radiographic bone density and immunohistochemical expression of osteopontin in newly formed regenerated bone
Subjects and methods: Patient with non-restorable maxillary anterior tooth or single root premolar that require extraction and dental implant. Test group: 13 extraction sites received particulate xenograft mixed with vitamin D3. Control group: 13 extraction sites received particulate xenograft alone. After 6 months implants were placed. Implant primary stability, radiographic bone density, immunohistochemical osteopontin expression in grafted sites were evaluated.
Results: A significantly higher mean value of both primary stability and bone density were recorded in test group.
Conclusion:
Taking in considerations the limitations of the current study, the addition of vitamin D to particulate xenogenic bone graft enhanced newly formed bone density, implant stability and is associated with increased expression of OPN level in grafted sites.

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Egyptian Dental Journal
Volume 71, Issue 2 - Serial Number 3
April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
April 2025
Pages 1401-1416

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