Evaluation of the levels of IL-33 in Periodontitis patients versus Peri-implantitis patients

Document Type : Original Article

Authors

1 Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

2 Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.

Abstract

Aim: The following study was carried out to evaluate comparatively the levels of IL 33 in periodontitis patients and Peri-implantitis patients.
Methods: A total of 60 patients with age ranged between 30 – 55 years, were selected. Detailed dental and medical histories were recorded, intraoral examinations were executed. Radiographs were also taken to evaluate alveolar bone destruction alveolar bone loss was found confirming the clinical periodontitis and Perimplantitis diagnosis. The participants were allocated into two groups. Group I (Periodontitis group) Thirty patients diagnosed having periodontitis. Group II (Peri-implantitis group) Thirty patients diagnosed having peri-implantitis. Samples of GCF were obtained from the selected site of all subjects in both groups. Following the manufacturer's instructions, the obtained commercial enzyme-linked human immunosorbent Assay (ELISA) Kit (Elabscience, USA) was used. Statistical analysis was done using the t-tests and Pearson's correlation analysis.
Results: When comparing the overall IL-33 levels between the two groups regardless of sex, the peri-implantitis group showed slightly higher levels (60.45 ± 19.92) compared to the periodontitis group (58.65 ± 17.90).
Conclusion: Concerning the current results of the study revealing elevated levels of GCF regarding periodontitis and peri-implantitis as disease entities. IL 33 can be used as a biomarker for identification and diagnosis of both diseases.

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Egyptian Dental Journal
Volume 71, Issue 2 - Serial Number 3
April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
April 2025
Pages 1433-1440

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