Injection of Hyperdiluted Radiesse hybrid with Belotero Balance for Interdental Papillary Regeneration: A Novel Combined Approach

Document Type : Original Article

Authors

1 MSc, Oral and Maxillofacial Surgery Specialist, Private Practice, Cairo, Egypt

2 Registered nurse practitioner

3 Doctor of Dental Surgery, Specialist of Cosmetology, Private practice, Serbia

4 Internal Medicine Doctor

Abstract

Objective: The loss of interdental papilla presents both aesthetic and functional concerns, often resulting in the formation of black triangles that compromise smile harmony. This study evaluates the efficacy of hyperdiluted calcium hydroxylapatite (CaHA) combined with hyaluronic acid (HA) as a minimally invasive injectable therapy for interdental papilla regeneration, aiming to restore soft tissue volume without inducing bone loss.

Methods: A prospective clinical study was conducted on patients exhibiting interdental papillary deficiency. Hyperdiluted Radiesse (CaHA) mixed with HA was precisely injected into the deficient papillary region using an insulin syringe. Objective assessments included digital caliper measurements of papillary height and volume, while subjective evaluations comprised patient satisfaction scores. Follow-ups were scheduled at baseline, 1 month, 3 months, and 6 months post-treatment. Statistical analysis was performed to compare pre- and post-procedure outcomes.

Results: A significant increase in papillary height and volume was observed across all patients, with the most pronounced improvements recorded at 3 months and sustained results at 6 months. Patients reported high satisfaction levels, with no complications such as infection, excessive inflammation, or underlying bone loss.

Conclusion: The use of hyperdiluted CaHA combined with HA filler represents a promising, minimally invasive approach for interdental papilla reconstruction. This technique offers aesthetic enhancement and patient satisfaction while preserving bone integrity. Future studies with larger sample sizes and extended follow-ups are warranted to confirm long-term efficacy and establish standardized treatment protocols.

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Egyptian Dental Journal
Volume 71, Issue 3 - Serial Number 2
July (Oral Surgery)
July 2025
Pages 2023-2030

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