The effect of MEBO topical application on healing tongue wound of albino rats

Document Type : Original Article

Author

oral biology department faculty of dentistry benisuef university benisuef egypt

Abstract

Objectives: The tongue is an essential organ in the human body. Because of the mechanical forces that surround it, it is more prone to injuries than other organs. In this study we investigated and contrasted self-healing and treated healing tongue wounds, tracking histological changes over a period of 3 to 7 days following wound induction. Design: 40 adult male Albino rats were utilized, 20 rats for group I and group II were sacrificed after 3 days from wound induction, group I was without taking any treatment , group II treated by MEBO topical application.20 rats were sacrificed after 7 days from wound induction for group III and IV. Group III was without treatment, group IV treated by topical application of MEBO. tongue was dissected and examined by H&E stain and MT stains. Results: The Histological results proved the potential effect of MEBO on wound healing of induced tongue wound. Theses results confirmed by statistical analysis by measuring the wound width and epithelium thickness. Wound width decreases during wound healing due to epithelial contraction. It decreases from 15.1 ± 2.30 in group I to 0.648 ± 0.840 in group IV with a high significant difference. Epithelium thickness increases from 2 ± 0.678 in group III to 4.28 ± 0.946 in group IV with a high significant difference . The Masson trichrome examination revealed a significant difference between in group III and group IV . Conclusion: results confirmed the high impact of topical application of MEBO on accelerating tongue wound healing

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Egyptian Dental Journal
Volume 71, Issue 3 - Serial Number 3
July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
July 2025
Pages 2103-2111

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