Aim: The current study aimed to compare the efficacy of scaling and root planing (SRP) alone versus sub-gingival curcumin local delivery gel in combination with scaling and root planing in the treatment of stage II grade B periodontitis in smokers. Subjects, materials and methods: In this double-blinded RCT, thirty smoker patients were treated with full-mouth nonsurgical SRP alone (control group) and full-mouth SRP followed by 2% local delivery curcumin gel (test group). Patients were observed at baseline, 30-day, and 45-day follow-ups to evaluate gingival index (GI), plaque index (PI) and clinical attachment level (CAL) parameters. Results: One Way ANOVA followed by Tukey`s post hoc test was used to analyse the data and revealed that GI and PI measurements among both groups showed statistically significant improvements over time. However, CAL showed a statistically significant difference over time in the test group only. Independent t-test for comparison between both groups demonstrated that the SRP with curcumin group had better reduction in GI and PI (0.8000, 0.6000 respectively) compared to the control group (1.400, 1.200 respectively), with a statistically significant difference at 45-day. CAL measurements between groups showed significant differences at both the 30-day (p=0.0168) and 45-day (p=0.0030) assessments. Conclusions Locally delivered curcumin gel improved the healing outcome of SRP in smokers, represented by a significant reduction in the gingival and plaque indices scores and a greater CAL gain compared to the mechanical debridement alone.
Abdelsamie, P., & Ibrahim El-Refai, I. (2025). Efficacy of curcumin local delivery gel for the treatment of Stage II Grade B periodontitis in smokers. Randomized controlled Clinical Trial.. Egyptian Dental Journal, 71(3), 2167-2175. doi: 10.21608/edj.2025.376054.3448
MLA
Parryhan M Abdelsamie; Ibrahim Mahmoud Ibrahim El-Refai. "Efficacy of curcumin local delivery gel for the treatment of Stage II Grade B periodontitis in smokers. Randomized controlled Clinical Trial.", Egyptian Dental Journal, 71, 3, 2025, 2167-2175. doi: 10.21608/edj.2025.376054.3448
HARVARD
Abdelsamie, P., Ibrahim El-Refai, I. (2025). 'Efficacy of curcumin local delivery gel for the treatment of Stage II Grade B periodontitis in smokers. Randomized controlled Clinical Trial.', Egyptian Dental Journal, 71(3), pp. 2167-2175. doi: 10.21608/edj.2025.376054.3448
VANCOUVER
Abdelsamie, P., Ibrahim El-Refai, I. Efficacy of curcumin local delivery gel for the treatment of Stage II Grade B periodontitis in smokers. Randomized controlled Clinical Trial.. Egyptian Dental Journal, 2025; 71(3): 2167-2175. doi: 10.21608/edj.2025.376054.3448
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