Purpose: Microbiological evaluation of the flora under prosthetic rehabilitation of facial defects Materials and Methods: Microbial evaluation of facial prostheses in twelve patients were done by taking eight samples, two samples from the tissue underlying the prostheses and the fitting surface of the prostheses at four observation time allover a year. These samples were cultured for microbial counts. The results were compared statistically with that of the samples from the same patient after different observations as well as with other patients receiving other prostheses using T-test. Result and conclusion: Staphylococcus aureus predominated in 90% of the patients. Staphylococcus epidermidis constituted the second most common microorganism 60% of the patients. Yeasts were isolated from 20 % of the patients. Corynebacterium, Escherichia coli, klebsiella were isolated also. The microbial count was greater in tissues underlying prostheses than in the fitting surface of the prostheses in the first three months, and by time the fitting surface of the prostheses increase in microbial count than that in tissues. Esthetically and hygienically, it is recommended to be replaced every year
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