Biocompatibility of different root canal sealers (In vivo study)

Document Type : Original Article

Authors

1 Lecturer of Endodontics , Assiut university

2 Associate Professor of Oral and Maxillofacial Pathology, Faculty of Dentistry, Assiut University

3 Lecturer at Endodontic department,Assuit university

Abstract

Aim: This study evaluated the biocompatibility of three different root canal sealers (CeraSeal, NeoSEALER Flo, and AH-Plus) by implanting them into the subcutaneous tissues of rats and analyzing the tissue response through histopathological and immunohistochemical methods.
Materials and Methods: Sixty male Calomys callosus (Rodentia, Cricetidae) rats were used. The sealers were placed in polyethylene tubes that were inserted into certain dorsal subdermal locations. After 3, 7, and 30 days, the implants were removed, fixed, and processed for microscopic inspection using a glycol methacrylate-embedding procedure.The descriptive analysis focused on fibrous capsule thickness, severity of the inflammatory response, presence of giant cells, and evidence of biomineralization.
Results: CeraSeal and the control group exhibited a milder inflammatory response compared to NeoSEALER Flo and AH-Plus. Additionally, the control group showed the thinnest fibrous capsule, followed by CeraSeal, while AH-Plus demonstrated the thickest capsule.
Conclusions: Within the limitations of this study, CeraSeal demonstrated superior biocompatibility compared to NeoSEALER Flo and AH-Plus sealers.

Keywords

Main Subjects

Egyptian Dental Journal
Volume 71, Issue 3 - Serial Number 5
Conservative Dentistry and Endodontics
July 2025
Pages 2735-2749

Files

Share

How to cite

Statistics