COULD INJECTABLE PRF (i-PRF) HOLD A HIDDEN ROLE IN PRESERVING PERIODONTAL HEALTH DURING TWO-STEP CANINE RETRACTION? A RANDOMIZED SPLIT-MOUTH CLINICAL TRIAL

Document Type : Original Article

Authors

1 MSc, Department of Orthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

2 Ass. Prof, Department of Orthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

3 Lecturer, Department of Orthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Abstract

Aim:This study aimed to evaluate the efficacy of injectable platelet-rich fibrin (i-PRF) in preserving periodontal health around canines during two-step retraction.
Material and
Methods:A randomized split-mouth controlled trial was conducted on 19 patients (mean age: 18 ± 3.85 years) undergoing fixed orthodontic treatment for bimaxillary protrusion or Class II Division 1 malocclusion required bilateral extractions of maxillary first premolars. In each patient, one quadrant was randomly assigned to receive i-PRF injections, while the contralateral side served as control with no injections. Following leveling and alignment, canine retraction was initiated using Niti closing springs delivering a150 g of force. i-PRF administered at four time points: three weeks before extraction (initial dose), T0, T2, and T4. Each injection targeted both buccal and palatal aspects of the canine at two vertical levels, in addition to an intraligamentary site. Periodontal parameters were assessed using a UNC-15 periodontal probe.

Results:At baseline (T0), probing depth was significantly lower in the intervention group (2.21 ± 0.51 mm) compared to the control group (2.35 ± 0.51 mm; P = 0.0001). However, no significant differences were observed between groups from T1 to T5. The overall mean probing depth remained slightly lower in the intervention group (P = 0.008), though within the clinically healthy range (≤ 3 mm). Intra-group changes were statistically significant in both groups, but marginal tissue loss between T0 and T5 was minimal and not significantly different (P = 0.14).

Conclusion:i-PRF provided no clinically meaningful advantage in maintaining probing depth or marginal tissue stability during canine retraction.

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Egyptian Dental Journal
Volume 71, Issue 4 - Serial Number 1
(Orthodontics, Pediatric & Preventive Dentistry)
October 2025
Pages 2845-2855

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