Assessment of injectable platelet-rich fibrin with hyaluronic acid versus Hyaluronic acid in management of temporomandibular joint internal derangement. (A randomized clinical trial)

Document Type : Original Article

Authors

1 Principal rresearcher at Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt.

2 Associate Professor at department of oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt.

3 Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Abstract

Objectives : To assess the effectiveness of injectable platelet rich fibrin (I-PRF) / Hyalronic acid (HA) versus HA injection following arthrocentesis in management of TMJ internal derangement. Materials and methods: A randomized controlled clinical trial of thirty patients with TMJ internal derangement were included according to the eligible criteria, and equally divided into three groups: arthrocentesis (Comparator 1), arthrocentesis with HA injection (Comparator 2), and arthrocentesis with HA and I-PRF injection (study). All groups were assessed clinically in terms of pain intensity ( 10 point -visual analogue scale/VAS). Pain score was recorded preoperatively and postoperatively ( 1 week, 1 month, and 3 months). Results: There was a significant reduction in VAS scores for pain intensity across all groups over time (p<0.001).. However, the arthrocentesis alone group showed the most pronounced reduction in pain scores compared to the other two groups. Conclusions: arthrocentesis is an effective treatment approach for temporomandibular joint internal derangement. The addition of HA or I-PRF+HA did not seem to provide a significant added benefit in terms of pain reduction over 3 months. Clinical Relevance: The results suggest that arthrocentesis alone may be a sufficient treatment approach for some patients.

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Egyptian Dental Journal
Volume 71, Issue 4 - Serial Number 2
October - Oral Surgery
October 2025
Pages 2997-3006

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