Two-Month Assessment of Solubility of Four Different Root Canal Sealers: A Comparative In Vitro Study

Document Type : Original Article

Authors

1 Associate Professor of Endodontics, Faculty of Dentistry, October University for Modern Sciences and Arts, Cairo, Egypt

2 Lecturer of Endodontics, Faculty of Dentistry, October University for Modern Sciences and Arts, Cairo, Egypt

Abstract

Aim: To evaluate and compare the solubility of four root canal sealers (Dia-Root BIO, Endofill, Sealapex, and AH Plus) at three intervals (24 hours, 30 days, and 60 days) and to assess whether each sealer’s solubility changes over time.
Materials and Methods: Solubility was assessed by measuring weight loss following immersion in distilled water at the specified intervals, based on standardized testing protocols. Data were statistically analyzed using SPSS software. One-way ANOVA followed by Tukey’s post hoc test was used to assess differences between sealers at each time interval, while repeated-measures ANOVA evaluated solubility changes within each sealer across time points. A significance level of p ≤ 0.05 was set for all tests.
Results: Statistically significant differences in solubility were observed among the sealers at each time interval (p < 0.05), except between AH Plus and Dia-Root BIO, which showed no significant difference. Both exhibited lower solubility values, while Endofill and Sealapex showed higher values, with Sealapex consistently exceeding Endofill at each time point. Although numerical increases in solubility were observed over time within each sealer, these changes were not statistically significant (p > 0.05).
Conclusion: Among the tested sealers, AH Plus and Dia-Root BIO consistently exhibited lower solubility values at all time intervals, suggesting potential for long-term sealing effectiveness. In contrast, although Sealapex and Endofill showed relatively stable behavior over time, their solubility values remained comparatively higher at each time interval. Selecting sealers with low solubility remains essential to enhance the longevity and success of endodontic treatment.

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Egyptian Dental Journal
Volume 71, Issue 4 - Serial Number 5
Conservative Dentistry and Endodontics
October 2025
Pages 3583-3590

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