Effect of Osteon II Collagen with Hyaluronic Acid on Osseointegration of simultaneous placed implant in piezoelectric splitted posterior mandibular alveolar ridge (Clinical and radiographic study)

Aim: The present study was designed to estimate clinically and radiographically effect of Osteon II Collagen with Hyaluronic Acid on osseointegration of simultaneous placed implant in posterior mandibular alveolar ridge after piezoelectric ridge splitting technique (RST) .
Patients & methods: This study was carried out on twenty one patients with partial edentulous narrow posterior mandibular alveolar ridge. Patients were divided randomly into three equal groups (group I treated by piezoelectric RST and simultaneous implant placement into their ridge; without any bone graft, group II treated by piezoelectric RST and simultaneous implant placement into their ridge which was grafted by Osteon II Collagen, while group III treated by piezoelectric RST and simultaneous implant placement into their ridge; associated with placement of Osteon II Collagen when mixed with Hyaluronic Acid in splitted alveolar ridge. Alveolar ridge in all group covered by guided tissue regeneration membrane after implant placement and bone grafting. Patients were evaluated clinically to assess probing depth (PPD), and implant stability quotient (ISQ) then radiographically to assess alveolar ridge width, marginal bone level (MBL), and bone density measurement (BD) parameters at 3, 6, 9 &12 months.
Results: Statistical analysis of PPD and ISQ results showed no significant difference between groups at the different intervals while MBL values showed that there is high statistical significant difference during 12 month interval when comparing group III vs. group II. On the same side, BD results showed that group III had highly statistical significant difference at all intervals when it was compared with group I. and at 6, 9 and 12 months when comparing G III vs. G II.
Conclusion: The present study concluded that Osteon II Collagen with Hyaluronic Acid may be adjunctive tool to accelerate bone osseointegration around immediate placed dental implant in posterior mandibular alveolar ridge after piezoelectric ridge splitting technique.