Biological behavior of 60/40 biphasic calcium phosphate and growth hormone mixture: in vivo study in dogs

Document Type : Original Article

Authors

1 Oral Medicine Division, Basic and Clinical Oral Sciences Department, Faculty of Dentistry, Um Al Qurra University, Saudi Arabia

2 Oral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine, Badr University, Egypt

3 Surgery, Anesthesiology, and Radiology, Faculty of Veterinary medicine, Suez Canal University.

4 Spectroscopy Department, Physics Division, National Research Centre, Egypt

Abstract


Grafting materials are important for ridge preservation procedures after tooth extraction. Ridge preservation prime value is the volume preservation for the healing sockets, which is needed for different ridge augmentation procedures.
Objective: Determine the healing responses of (local growth hormone, and biphasic calcium phosphate mixture 60/40 in fresh extraction sockets of a canine model.
Materials and Methods: Six mongrel dogs included in this study; they were divided into 2 groups according to the time of sacrifice (4 and 8 weeks). Each of these groups includes three animals. Animals subjected to extraction of the fourth premolar bilaterally, The right side treated with a mixture of 4 IU (1.6 mg) Growth hormone and biphasic calcium phosphate (a composite of hydroxyapatite HA and bèta-tricalcium phosphate TCP 1 x 0.15 ml (450-650 µm) in a granular form, while the left side left as a control. The healing extraction sockets were evaluated by surface electron microscope (SEM).
Results: Scanning electron microscope examination showed homogenous new bone formation in both groups. Control group showed significant results as regard calcium phosphate ratio in the first month, while non-significant result was encountered in the second month between two groups.
Conclusion:. Single local dose of growth hormone mixed with 60/40 biphasic calcium phosphate did not improve calcium phosphate ratio.

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