Coenzyme Q10 Food Supplement on the Treatment of Chronic Periodontitis in Patients with Type II Diabetes Mellitus: A Randomized Control Study

The ultimate goal of the present study was, to evaluate the effectiveness of Coenzyme Q10 (CoQ 10) supplementation as an adjunct to scaling and root planing in reducing gingival inflammation and periodontal tissue destruction in chronic periodontitis patients with type II diabetes mellitus (DM).
Material and Methods: Thirty patients with chronic periodontitis and type II DM were equally divided into 2 groups. Group I received scaling and root planing plus placebo capsule for 3 months and groups II received scaling and root planing and Coenzyme Q10 for 3 months. Bleeding on probing and gingival index were taken at baseline,1, 3 and 6 months’ evaluation periods while probing pocket depth, clinical attachment loss at baseline, 3 and 6 months only. Gingival crevicular fluid (GCF) samples were collected for measuring matrix metalloproteinase -8 (MMP-8) in GCF at baseline,1, 3 and 6 months’ evaluation periods.
Results: Statistical analyses demonstrated a significant reduction in clinical parameters from baseline to 6 months in group II (test group) as compared to their baseline value P<0.001, while control group showed improvement in clinical parameters up to 3 months only followed by statistically insignificant increase in the mean scores of the tested parameters at 6 months as compared to baseline values P>0.05. Intergroup comparison showed statistically significant differences between the two studied groups at all the study evaluation periods in favor to group II (test group). GCF-MMP-8 levels showed statistically significant continual reduction from baseline up to 3 months followed by slight increase at 6 months which is still below baseline value for both group PConclusions: from the results of the present study it is clear that dietary supplementation with CoQ 10 may provide a low-cost intervention to augment periodontal therapy. Hence, CoQ 10 as an antioxidant could be used safely as an effective adjunct to oral prophylaxis in treatment of chronic periodontitis in diabetic patients.