Aim: This study was conducted to compare the diagnostic accuracy of CBCT imaging to digital panoramic imaging in assessment of osteoarthritic TMJ osseous changes. Methods: 25 patients were enrolled in the current investigation, divided into two groups, Group (1) the diseased group including fifteen patients. Group (2) the control group including Ten normal asymptomatic healthy patients (20 joints) but they were seeking for treatment of other dental problems, in the two groups enrolled in this study all participants were females with ages ranging between 25-55 years. All participants were scanned with panoramic and cone beam computed tomography (CBCT). Results: ROC curve analysis of panoramic views showed diagnostic accuracy 76.4% while diagnostic accuracy of CBCT (TMJ views) was 81.3% and CBCT (Sagittal views) showed 82.6% diagnostic accuracy. Conclusion: Panoramic images can be used as a preliminary valuable tool for evaluation of osteoarthritic osseous changes equivalent to CBCT images as it revealed relatively high sensitivity compared to CBCT images.