Assessment of IL-17 in Oral Lichen Planus and in Pemphigus Vulgaris

Document Type : Original Article

Authors

1 Lecturer, Oral Medicine & Periodontology Department, Faculty of Dentistry, Cairo University - Egypt

2 Associate Professor, Oral Medicine & Periodontology Department, Faculty of Dentistry, Cairo University - Egypt

3 Lecturer, Dermatology Department, Faculty of Medicine Cairo University-Egypt

Abstract

Background: the present study was aimed to evaluate the levels of IL-17 as a core cytokine and a diagnostic marker of both OLP and PV for comparison and evaluation regarding saliva and serum.
Subjects and Methods: The present study was performed on a total of 45 subjects divided into 3 groups Group I Fifteen patients diagnosed with OLP Group II Fifteen patients diagnosed with PV with oral lesions and Group III Fifteen healthy patients (control Group). Salivary and serum samples were collected from all participating subjects for determination of IL-17 levels using enzyme-linked immunosorbent assay (ELISA).
Results: Mean IL-17 levels in saliva of OLP group were significantly higher statistically than PV patients and control subjects with p values 0.12 and 0.03 respectively. Serum levels of IL-17 in OLP and PV patients were higher compared to control subjects with a statistically significant p value of Conclusion: According to the results the high serum and salivary levels of IL-17 in OLP patients when compared to healthy control group or PV group suggested that it could be used as a diagnostic marker for OLP and could be used to differentiate it from PV.

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