Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population

Document Type : Original Article

Authors

1 Associate professor in Department of Oral Medicine and Periodontology, Faculty of dentistry, Cairo University.

2 Professor in Department of Biochemistry, Faculty of Medicine, Cairo University.

Abstract

Background: AGEs are formed under oxidative conditions and are called advanced glyco-xidation end products. Periodontitis is a multifactorial inflammatory condition. The periodontal tissue damage is caused directly by bacteria and indirectly by inflammation and immunologic response against the bacteria. This inflammatory response is characterized by generation of prolonged release of neutrophil proteolytic enzymes, pro-inflammatory mediators and reactive oxygen species (ROS). Therefore, periodontitis is strictly linked to numerous pathologies which are related to production of oxidative stress and AGEs.
Methods: The study was conducted on thirty participants, they were divided into two groups; group (A) which included fifteen medically free subjects, and group (B) which included fifteen patients suffering from periodontitis. Serum and GCF samples were collected for assessment of AGEs before and after non -surgical periodontal therapy. Data were analysed by SPSS.
Results: Periodontitis group showed statistically significant higher mean AGE levels than control group in both serum and GCF samples. Moreover, there was a statistically significant decrease in AGE levels in both serum and GCF after treatment.
Conclusion: Crevicular level of AGEs can be used as a non-invasive diagnostic and prognostic biomarker for periodontitis.

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