Clinical and Cone-beam Computed Tomography Evaluation of Xenograft alone or in combination with Platelet Rich Fibrin in the Treatment of Grade II Mandibular Furcation Involvement

Aim of study: The aim of this study was to compare the effect of Xenograft alone or in combination with Platelet rich fibrin (PRF) in the treatment of mandibular furcation grade II defects.
Patients and methods: Twenty patients with a total number of 40 grade II furcation defects in split mouth design determined clinically and radiographically were selected for the study. The selected sites were treated with open flap surgery and divided into two groups: Group I was treated with Xenograft (cerabone®) only and Group II treated with Xenograft (cerabone®) plus PRF membrane. The clinical and radiographic evaluation occurred at baseline (before surgery) and 6 month post-operative. Clinical parameters include: plaque index (PI), gingival index (GI), vertical clinical attachment level (VCAL) and Horizontal clinical attachment level (HCAL). Cone-beam Computed Tomography (CBCT) was performed to measure furcation height (FH), width (FW), and depth (FD) defects of mandibular molars at baseline (before surgery) and 6 month post-operative.
Results: Both groups showed statistically significant reduction in all clinical and radiographic parameters within groups from baseline to 6 months post-operative. HCAL, FH, FW and FD were significantly increased in G II compared to G I at 6 months post-operative.
Conclusion: Treatment of furcation grade II defects with xenograft (cerabone®) plus PRF led to significant improvement more than xenograft (cerabone®) alone.