CYTOTOXICITY OF REGULAR AND FAST SET BIOCRAMIC MATERIALS

Document Type : Original Article

Author

Assistant Professor, Department of Endodontics, Faculty of Dentistry, King Abdulaziz University

Abstract

Aim: To compare the cytotoxic effect of regular and fast set Root Repair Materials using oral epithelial cells (OEC).
Materials and methods: The cytotoxicity of the two forms was tested against OEC cells using Sulfo-rhodamine B (SRB) assay. The cells were exposed to the test compound for 72 hrs.
Results: Both fast and regular set root repair materials showed a considerable cytotoxicity against OEC cells with IC50 of 3.0 and 3.4 μg/ml, respectively. Despite their moderate cytotoxic effect, the resistant fraction was relatively high for Fast and regular root repair composites
(R-values equal 35.6% and 32.2%, respectively).
Conclusions: Both fast and regular set of EndoSequence Root Repair Materials have a considerable cytotoxicity against OEC cells. Despite their moderate cytotoxic effect against the cells the resistant fraction was relatively high for both.