FOURIER TRANSFORM INFRARED SPECTROSCOPIC ANALYSIS FOR HEALING SOCKETS TREATED WITH A MIXTURE OF GROWTH HORMONE AND BIPHASIC CALCIUM PHOSPHATE: EXPERIMENTAL STUDY ON DOGS

Document Type : Original Article

Authors

1 Oral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine, Nahda University, Beni Suef, Egypt.

2 Oral Medicine Division, Basic and Clinical Oral Sciences Department, Faculty of Dentistry, Um Al Qurra University, Saudi Arabia.

3 Surgery, Anesthesiology, and Radiology, Faculty of Veterinary medicine, Suez Canal University

4 Spectroscopy Department,Physics Division, National Research Centre, Egypt.

Abstract

The primary goal of alveolar ridge preservation procedures is volume preservation, the volume preserved by encouraging new bone formation in healing sockets. About 90% of patients referred for implant therapy must perform these procedures after extraction that employs the placement of grafting materials.
Objective: Evaluate and characterize the healing responses of Growth hormone, and bicalcium phosphate mixture in tooth extraction sockets of a canine model.
Materials and Methods: Six mongrel dogs were included in this study; they were divided into 2 groups according to the time of sacrifice (4 and 8 weeks). Each of these groups includes three animals. Animals were subjected to extraction of the third premolar bilaterally, The right side was treated with a mixture of 4 IU (1.6mg) Growth hormone and easy-graft TM (a composite of hydroxyapatite and bèta-tricalcium phosphate – crystal ) 1 x 0.15 ml (450-650 µm) in a granular form before wound closure while the left side was left as a control. The healing extraction sockets were evaluated by Fourier Transform Infrared spectroscopic analysis.
Results: All sockets healed without complications. Growth hormone and biphasic calcium phosphate groups showed new bone formation comparable to that of native bone.
Conclusion: The grafted sockets demonstrated acceptable biodegradability at 4 and 8 weeks postoperatively. The new bone formation was not delayed because of the graft.

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