CLINICAL AND RADIOGRAPHIC EVALUATION OF CORTICO-CANCELLOUS BONE MIX XENOGRAFT (OSTEOBIOL GEN-OS®) IN THE TREATMENT OF HUMAN PERIODONTAL INTRABONY DEFECTS

Background and objective: Bone substitutes are widely used to promote bone formation and periodontal regeneration. The aim of this study was to compare the clinical and radiographic effectiveness of cortico-cancellous bone mix xenograft (Osteobiol Gen-Os) in the treatment of intrabony defects.
Materials and methods: Twenty systemically healthy chronic periodontitis patients, radiographic observation showed vertical intrabony defect of ≥ 5 mm after non-surgical periodontal therapy, subjects were categorized into group 1 (G1) treated by xenogrfat and group 2 (G2) treated by open flap debridement only. At baseline, 6 and 12 month after surgery the patients were evaluated clinically by: plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL), and radiographically to measure the bone density and reduction of intrabony defect depth.
Results: Significantly clinical improvements of PI and GI were observed in both groups. In G1, The mean values of PD and CAL were representing highly significant differences between the three time intervals (baseline, 6 and 12 month, (P ≤ 0.01). In G2, the statistical comparisons between the mean values of PD at 3 time intervals, also CAL mean values at 6 month versus baseline were highly significant (P ≤ 0.01). Radiographically, the bone density and reduction of defect depth were improved in G1 compared to G2. The mean values of bone density and reduction of defect depth were high significantly increased in G1 versus G2 at 6 and 12 month (P ≤ 0.01).
Conclusions: The results of the current study indicated that cortico-cancellous xenograft (Osteobiol Gen-Os) significantly improved of clinical and radiographic outcomes over the course of the study.