EVALUATION OF THE SALIVARY LEVEL OF MIR-21 IN CIGARETTE SMOKERS: CASE-CONTROL STUDY

Document Type : Original Article

Authors

1 Lecturer, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University

2 Associate Professor, Department of Medical Biochemistry, Faculty of Pharmacy, Ahram Canadian University.

Abstract

Background: Salivary biomarkers are attractive non-invasive tools for screening oral cancer especially in high risk individuals such as smokers. The present study observed the salivary level of microRNA-21 to verify their value as diagnostic marker for smokers.
Methods: The study sample comprised 40 males: 20 non-smokers and 20 smokers. Whole unstimulated saliva samples were collected. The resulting data was analyzed for any statistical significance.
Results: Smokers had statistically significant higher salivary microRNA-21 level than non-smokers.
Conclusions: Our study demonstrated elevated levels of salivary microRNA-21 in cigarette smokers. Salivary miR-21 could be a promising new diagnostic marker for cigarette smokers.
We recommend conducting further studies to investigate its diagnostic value as a marker for oral cancer susceptibility in cigarette smokers.

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