Anatomical variability in the maxillary sinus volume has been studied and reported by several researchers. Objective: The purpose of the present study was to assess the variety in the maxillary sinus volume between genders and between the right and left sides using cone beam computed volumetric imaging. Methods: The present retrospective study was carried on fifty cone beam computed tomography (CBCT) records of adult Egyptians aging from 20-40 years. The records were equally partitioned into two groups; the male group (G1) and the female group (G2). Volumetric examination of the antrum was conducted and statistically analyzed to compare between right and left sides and between males and females. Results: Statistically significant differences was found in the antral volume between male and female subjects as well as between the right and left sides. Conclusion: The volume of the maxillary sinus (MS) in male subjects was larger than the female subjects, in addition, the right-side volume was found to be larger than the left side for both genders.