Objectives: This study was conducted to measure the effect of growth factors and cytokines present in platelet rich fibrin (PRF) on the stability of immediately placed implants as measured by resonance frequency analysis for implant overdentures. Materials and Methods: Seven patients with one remaining cuspid or bicuspid indicated for extraction on each side of the mandibular arch were selected for the study. After atraumatic extraction, the first implant was inserted without grafting material while the second implant was placed with PRF grafting material. Implant stability was measured using resonance frequency analysis by the Osstelle device at the time of implant placement and at 2, 4, 6 and 8 weeks after implant placement. An implant overdenture using Locator attachments was fabricated and delivered to each patient. Results: The results of this study showed higher ISQ values for the second implant than the first implant at the time of implant placement, but the difference was not statistically significant. A statistically significant increase in implant stability for both implants was found at all follow-up appointments. On comparing the two implants, the second implant had significantly higher implant stability quotient (ISQ) values at every follow-up appointment than the first implant. At the end of the 8-week follow-up period, the second implant showed significantly higher ISQ values than the first implant. Conclusions: Growth factors and cytokines present within PRF grafting material can be used with immediate implant placement to enhance implant stability of during the early stages of healing.
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