Effect of non surgical periodontal therapy combined with doxycycline on the levels of gingival crevicular fluid of nitric oxide

Authors

1 Demostrator at Oral Medicine, Diagnosis and Periodontology Department, Faculty of Oral and Dental Medicine- Nahda University

2 Prof. of Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Minia University

3 Ass. Prof. of Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Suez Canal University

4 Lecturer of Oral Medicine, Oral Diagnosis and Periodontology Departmement Faculty of Dentistry, Minia University

Abstract

Reactive oxygen species (ROS) and antioxidant activity have been involved in pathogenesis of periodontitis and investigated by many studies. Nitric oxide (No) one of ROS plays important role in increase pathogenesis of periodontal disease. Tetracycline derivatives like doxycycline is considered a ROS scavenger. It works as antioxidant, lessen oxidative stress and improve NO
bioavailability.

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