BONE MORPHOGENIC PROTEIN EXPRESSION OF INDUCED MEMBRANE USING TWO TYPES OF POLYMETHYL METHACRYLATE SPACERS IN MANDIBULAR SEGMENTAL DEFECTS: AN EXPERIMENTAL STUDY

Document Type : Original Article

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Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt

Abstract

Aim: The aim of this study was to evaluate bone morphogenic protein-2 (BMP-2) expression in the induced membrane formed around mandibular segmental defect filled with 2 types of polymethyl methacrylate (PMMA) spacer over a period of 2, 4, 6 and 8 weeks, and to question whether the use of dental self cure acrylic resin spacer instead of PMMA bone cement spacer affect histological and osteopromotive characters of the induced membrane
Materials and methods: This study was conducted on 24 healthy male mongrel dogs. For each animal segmental mandibular resection was performed to create a critical size defect. The defect is filled with PMMA bone cement spacer in 12 animals, while for the other 12 animals the spacers were fabricated from self cure acrylic resin. 6 dogs (3 dogs from test group and 3 from control group) were scarified at 2, 4, 6 and 8 weeks postoperatively for histological and immunohistochemical analysis.
Results: Histological result showed similar reaction in both groups. Immunohistological results showed that 4th week represents the peak of BMP-2 expression in both groups.
Conclusion: This study indicated that the optimal time for reconstruction is 4 weeks after spacer insertion. It also showed that dental self cure acrylic resin can be used instead of PMMA bone cement

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