Aim of the study: To compare the antibacterial effect of ActivGPsealer (Glass Ionomer based) (Brasseler, Savannah, USA) versus AD seal (Resin based sealer) (META, Chungcheongbuk-do, Korea) and AH 26 sealer (Resin based sealer) (Densply, USA) against E-faecalis using agar diffusion method. Samples were classified into 3 groups according to the material used Group 1: Activ GP sealer, Group 2: AD seal and group 3; AH 26. Each group was classified into three subgroups according to the observation periods (1 day, 3 days and 7 days). Each group consisted of 7 agar plates implanted with E-faecalis strain. 3 holes were created in each agar plate each hole contained one tested material. The results showed that the AH Plus exhibited the largest inhibitory zone followed by Activ GP which exhibited the anti bacterial activity only after 3 days while AD seal exhibited no antibacterial activity. It has been concluded that the antimicrobial activity of AH Plus was greater than Activ GP, which were more efficient in bacterial inhibition than AD seal.
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