COMPARISON BETWEEN LOCAL APPLICATION OF DOXYCYCLINE LOADED NANOPARTICLES AND CONVENTIONAL DOXYCYCLINE GEL ON MATRIX METALLOPROTEINASE 1 AND BONE DENSITY IN CHRONIC PERIODONTITIS

Background & Objective: Nanoparticles have received considerable attention in recent years. This study was conducted to compare between doxycycline loaded nanoparticles (DLNs) and conventional doxycycline gel (CDG) in management of chronic periodontitis (CP).
Materials and Methods: This randomized, split mouth study was conducted on 40 sites among 20 patients with chronic periodontitis. The sites were randomly allocated into a control group, receiving scaling and root planing (SRP) plus CDG, and an experimental group, receiving SRP plus DLNs. Clinical parameters and levels of matrix metalloproteinase 1 (MMP1) were assessed at baseline, 1, 3 and 6 months post treatment. Bone density was also assessed at baseline and 6 months after treatment.
Results: The results, following the use of both treatment gel formulas, showed a statistically significant reduction in all tested clinical parameters and levels of MMP1 at 1, 3 and 6 months post treatment along with significant increase in bone density after 6 months. However, DLNs treatment achieved a significant reduction not only in clinical parameters but also in MMP1 as compared to CDG treated group. In addition, The DLNs showed a significant bone formation as compared to CDG group.
Conclusion: DLNs shows promise as adjunctive local therapy for management of patients with chronic periodontitis.
Clinical Relevance: Scientific Rationale for Study: Evaluating the effect of doxycycline loaded nanoparticles gel and conventional doxycycline gel on treatment of chronic periodontitis. Principal Findings: Findings from this randomized, split mouth study of 40 sites among 20 patients with chronic periodontitis supported the potential of doxycycline loaded nanoparticles and conventional doxycycline gel for providing an effective therapy for chronic periodontitis, along with improving clinical parameter, bone density and decreasing matrix metalloproteinase 1. Practical Implications: Doxycycline loaded nanoparticles are proved to be more effective than conventional doxycycline gel as an adjunctive treatment of chronic periodontitis.