Introduction: Ulcers are one of the most frequent diseases affecting the oral cavity. The aim of this study was to assess the impact of omega-3 on healing of buccal traumatic ulcer in rat. Materials and methods: In this study adult male rats in 2 groups (n = 15 per group) were used. A wound circular in shape (4 mm diameter and 2 mm depth) was punched into the buccal mucosa of each rat using biopsy punch. The control group was not treated, the study group was treated with 93mg/kg body weight omega-3 that was guided to the stomach by gastric gavage. Histological samples were harvested on post-injury days 3, 7 and 14. Results: The study group had high reepithelialization and connective tissue healing score on day 7 and 14. The control group had high inflammation score on day 3 and 7, and low reepithelializtion score on day 3, 7 and 14. Conclusion: Omega-3 compound increases fibroblast counts and decreases inflammatory cell counts, and also causes an increase in reepithelialization and epithelial thickness.
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