Aim: The purpose of this study was to compare solubility, pH, calcium ion release and setting time of Biodentine, Bioaggregate, and Bioactive glass. Materials and Methods: For the weight loss, pH changes and calcium ions release, the tested specimens were immersed in distilled water. The evaluations were performed at 1h, 24h and 7 d. The measurement of pH was done using digital pH meter. The measurement for Ca2+ ions release was done using atomic absorption spectrophotometry. The setting time was measured by using a Vicat apparatus. Data were analyzed by One Way ANOVA test and the Tukey post-hoc test at P ≤ 0.05. Results: Biodentine showed the greatest solubility, ultimate increase in pH, and highest calcium ion release at all time intervals and the shortest setting time. Bioactive glass showed alkalinity and moderate Ca2+ release after 1 h that were decreased by time. It also showed negative solubility. Conclusions: Biodentine and Bioaggregate favored proper physico-chemical properties except for solubility it was questionable. Bioactive glass is the best regarding solubility. Keywords: Bioactive glass, Bioaggregate, Biodentine , Physico-Chemical properties.
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